Mohamed Eid1, Amr Mounir2, Shehab El Etriby3, Ali Al Taher1, Mohamed A W Ezzat1. 1. Department of Internal Medicine, Sohag University Hospital, Sohag University, Sohag, Egypt. 2. Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt. 3. Department of Cardiology, Ain Shams Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Background: Diabetic retinopathy (DR) is one of the most prevalent consequences of diabetes mellitus (DM). Much emphasis has been focused on the link between DR and cardiovascular disorders in patients with type 2 diabetes (T2DM). However, there is little information about the relation between the degree of DR and coronary atherosclerosis severity in Egyptian patients. Aim: To assess the correlation between the degree of DR and the coronary atherosclerosis severity in T2DM. Patients and Methods: This work included 140 diabetic patients with T2DM who underwent diagnostic coronary angiography because of suspected coronary artery disease (CAD). All participants were evaluated by history, fundus assessment, laboratory tests (lipid profile and glycated hemoglobin [HbA1c]), and selective coronary angiography. The severity of coronary artery lesion was detected by Gensini score and vessel score. Results: Patients with DR had a significantly higher Gensini score (67.86± 44.56 versus 5.93± 9.02, P < 0.001) and a vessel score (2.29± 0.86 versus 0.50± 0.66, P < 0.001). There was a significant relation between the degree of DR, Gensini score (P < 0.001), and vessel score (P < 0.001), as both scores increased according to the severity of DR. The presence and degree of retinopathy were the only independent factors linked to the severity score in multivariate linear regression analyses (P < 0.001). Conclusion: The presence and degree of DR are independent predictors of severe coronary atherosclerosis. Therefore, when evaluating whether a patient with T2DM is at high risk for CAD, the DR degree should be taken into consideration.
Background: Diabetic retinopathy (DR) is one of the most prevalent consequences of diabetes mellitus (DM). Much emphasis has been focused on the link between DR and cardiovascular disorders in patients with type 2 diabetes (T2DM). However, there is little information about the relation between the degree of DR and coronary atherosclerosis severity in Egyptian patients. Aim: To assess the correlation between the degree of DR and the coronary atherosclerosis severity in T2DM. Patients and Methods: This work included 140 diabetic patients with T2DM who underwent diagnostic coronary angiography because of suspected coronary artery disease (CAD). All participants were evaluated by history, fundus assessment, laboratory tests (lipid profile and glycated hemoglobin [HbA1c]), and selective coronary angiography. The severity of coronary artery lesion was detected by Gensini score and vessel score. Results: Patients with DR had a significantly higher Gensini score (67.86± 44.56 versus 5.93± 9.02, P < 0.001) and a vessel score (2.29± 0.86 versus 0.50± 0.66, P < 0.001). There was a significant relation between the degree of DR, Gensini score (P < 0.001), and vessel score (P < 0.001), as both scores increased according to the severity of DR. The presence and degree of retinopathy were the only independent factors linked to the severity score in multivariate linear regression analyses (P < 0.001). Conclusion: The presence and degree of DR are independent predictors of severe coronary atherosclerosis. Therefore, when evaluating whether a patient with T2DM is at high risk for CAD, the DR degree should be taken into consideration.
Authors: Scott M Grundy; Neil J Stone; Alison L Bailey; Craig Beam; Kim K Birtcher; Roger S Blumenthal; Lynne T Braun; Sarah de Ferranti; Joseph Faiella-Tommasino; Daniel E Forman; Ronald Goldberg; Paul A Heidenreich; Mark A Hlatky; Daniel W Jones; Donald Lloyd-Jones; Nuria Lopez-Pajares; Chiadi E Ndumele; Carl E Orringer; Carmen A Peralta; Joseph J Saseen; Sidney C Smith; Laurence Sperling; Salim S Virani; Joseph Yeboah Journal: J Am Coll Cardiol Date: 2018-11-10 Impact factor: 24.094
Authors: Kenneth F Adams; Arthur Schatzkin; Tamara B Harris; Victor Kipnis; Traci Mouw; Rachel Ballard-Barbash; Albert Hollenbeck; Michael F Leitzmann Journal: N Engl J Med Date: 2006-08-22 Impact factor: 91.245
Authors: S Vigili de Kreutzenberg; A Coracina; A Volpi; G P Fadini; A C Frigo; G Guarneri; A Tiengo; A Avogaro Journal: Nutr Metab Cardiovasc Dis Date: 2010-02-16 Impact factor: 4.222
Authors: David A Halon; Mali Azencot; Ronen Rubinshtein; Barak Zafrir; Moshe Y Flugelman; Basil S Lewis Journal: J Am Heart Assoc Date: 2016-06-13 Impact factor: 5.501
Authors: Daniel G Sedding; Erin C Boyle; Jasper A F Demandt; Judith C Sluimer; Jochen Dutzmann; Axel Haverich; Johann Bauersachs Journal: Front Immunol Date: 2018-04-17 Impact factor: 7.561