Alessandra Mayer1, Gaia Francescato2, Nicola Pesenti3, Federico Schena4, Fabio Mosca1,5. 1. NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 2. NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. gaia.francescato@yahoo.it. 3. Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, University of Milano-Bicocca, Milan, Italy. 4. Neonatal Intensive Care Unit - AO SS Antonio e Biagio e C. Arrigo Hospital, Alessandria, Italy. 5. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Abstract
OBJECTIVE: To assess whether either duration and magnitude of ductal shunt or medical treatment for patent ductus arteriosus (PDA) are related to spontaneous intestinal perforation (SIP). STUDY DESIGN: Clinical charts of infants <29 weeks' gestation born from 2006 to 2018 were reviewed. Echocardiographic examinations were evaluated according to McNamara and Sehgal's staging system. RESULTS: A higher percentage of patients with SIP had a hemodynamically significant PDA (HSPDA) and was treated with either NSAIDs or paracetamol (79% vs 53% and 81% vs 54%, respectively). Among non-treated patients, we found a 1.32 increase in the odds of SIP per day of persistence of HSPDA. In the cohort of patients treated despite the absence of HSPDA, we found a 2.35 increase in the odds of SIP per dose of drug administered. CONCLUSION: Both treating a non-HSPDA and leaving a HSPDA to its natural history seem to be associated with SIP.
OBJECTIVE: To assess whether either duration and magnitude of ductal shunt or medical treatment for patent ductus arteriosus (PDA) are related to spontaneous intestinal perforation (SIP). STUDY DESIGN: Clinical charts of infants <29 weeks' gestation born from 2006 to 2018 were reviewed. Echocardiographic examinations were evaluated according to McNamara and Sehgal's staging system. RESULTS: A higher percentage of patients with SIP had a hemodynamically significant PDA (HSPDA) and was treated with either NSAIDs or paracetamol (79% vs 53% and 81% vs 54%, respectively). Among non-treated patients, we found a 1.32 increase in the odds of SIP per day of persistence of HSPDA. In the cohort of patients treated despite the absence of HSPDA, we found a 2.35 increase in the odds of SIP per dose of drug administered. CONCLUSION: Both treating a non-HSPDA and leaving a HSPDA to its natural history seem to be associated with SIP.
Authors: Rajan Wadhawan; William Oh; Betty R Vohr; Shampa Saha; Abhik Das; Edward F Bell; Abbott Laptook; Seetha Shankaran; Barbara J Stoll; Michele C Walsh; Rose Higgins Journal: Arch Dis Child Fetal Neonatal Ed Date: 2012-06-09 Impact factor: 5.747
Authors: R Wadhawan; W Oh; S R Hintz; M L Blakely; A Das; E F Bell; S Saha; A R Laptook; S Shankaran; B J Stoll; M C Walsh; R D Higgins Journal: J Perinatol Date: 2013-10-17 Impact factor: 2.521