Xiao-Dong Zhang1, Jing-Li Li2, Jia-Min Zhou1, Zi-Ning Lu1, Lin-Ru Zhao3, Wen Shen1, Jun-Hai Xu4, Yue Cheng5. 1. Department of Radiology, Tianjin First Central Hospital, Tianjin Institute of Imaging Medicine, No.24 Fu Kang Road, Nan Kai District, Tianjin, 300192, China. 2. Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 300060, China. 3. Department of Rheumatology, Tianjin First Central Hospital, Tianjin, 300192, China. 4. Tianjin Key Laboratory of Cognitive Computing and Application, College of Intelligence and Computing, Tianjin University, Tianjin, 300350, China. jhxu@tju.edu.cn. 5. Department of Radiology, Tianjin First Central Hospital, Tianjin Institute of Imaging Medicine, No.24 Fu Kang Road, Nan Kai District, Tianjin, 300192, China. chengyue200017076@163.com.
Abstract
PURPOSE: Cognitive impairment has been revealed in primary Sjögren's syndrome (pSS). However, the underlying white matter structural connectivity (SC) changes have not been studied. This study aimed to investigate the altered white matter brain network in patients with pSS using diffusion tensor imaging (DTI). METHODS: Forty-one pSS patients and sixty matched healthy controls (HCs) underwent neuropsychological tests and the subsequent MRI examinations. The clinical data were gathered from the medical record. The structural brain network was established using DTI, and a link-based comparison was performed between patients with pSS and HCs (false discovery rate correction, P < 0.05). Furthermore, the mean fractional anisotropy (FA) of the altered SCs was correlated with the neuropsychological tests and clinical data in patients with pSS (Bonferroni correction, P < 0.05). RESULTS: Compared with HCs, patients with pSS mainly exhibited decreased SC in the frontal and parietal lobes and some parts of the temporal and occipital lobes. In addition, increased SC was found between the right caudate nucleus and right median cingulate/paracingulate gyri. Specifically, the reduced SC between the left middle temporal gyrus and left middle occipital gyrus was negatively correlated with white matter high signal intensity (WMH). CONCLUSIONS: Patients with pSS showed diffusely decreased SC mainly in the frontoparietal network and exhibited a negative correlation between the reduced SC and WMH. SC represents a potential biomarker for preclinical brain impairment in patients with pSS.
PURPOSE: Cognitive impairment has been revealed in primary Sjögren's syndrome (pSS). However, the underlying white matter structural connectivity (SC) changes have not been studied. This study aimed to investigate the altered white matter brain network in patients with pSS using diffusion tensor imaging (DTI). METHODS: Forty-one pSS patients and sixty matched healthy controls (HCs) underwent neuropsychological tests and the subsequent MRI examinations. The clinical data were gathered from the medical record. The structural brain network was established using DTI, and a link-based comparison was performed between patients with pSS and HCs (false discovery rate correction, P < 0.05). Furthermore, the mean fractional anisotropy (FA) of the altered SCs was correlated with the neuropsychological tests and clinical data in patients with pSS (Bonferroni correction, P < 0.05). RESULTS: Compared with HCs, patients with pSS mainly exhibited decreased SC in the frontal and parietal lobes and some parts of the temporal and occipital lobes. In addition, increased SC was found between the right caudate nucleus and right median cingulate/paracingulate gyri. Specifically, the reduced SC between the left middle temporal gyrus and left middle occipital gyrus was negatively correlated with white matter high signal intensity (WMH). CONCLUSIONS: Patients with pSS showed diffusely decreased SC mainly in the frontoparietal network and exhibited a negative correlation between the reduced SC and WMH. SC represents a potential biomarker for preclinical brain impairment in patients with pSS.
Authors: Maria B Lauvsnes; Mona K Beyer; Jan Terje Kvaløy; Ole J Greve; Simone Appenzeller; Ingeborg Kvivik; Erna Harboe; Anne B Tjensvoll; Lasse G Gøransson; Roald Omdal Journal: Arthritis Rheumatol Date: 2014-12 Impact factor: 10.995
Authors: M B Lauvsnes; M K Beyer; S Appenzeller; O J Greve; E Harboe; L G Gøransson; A B Tjensvoll; R Omdal Journal: Eur J Neurol Date: 2014-06-19 Impact factor: 6.089
Authors: M Akasbi; J Berenguer; A Saiz; P Brito-Zerón; M Pérez-De-Lis; A Bové; C Diaz-Lagares; S Retamozo; Y Blanco; R Perez-Alvarez; X Bosch; A Sisó; F Graus; M Ramos-Casals Journal: QJM Date: 2011-12-07
Authors: L C Tzarouchi; A K Zikou; N Tsifetaki; L G Astrakas; S Konitsiotis; P Voulgari; A Drosos; M I Argyropoulou Journal: AJNR Am J Neuroradiol Date: 2013-11-01 Impact factor: 3.825