Disposal practices of unused and expired pharmaceuticals among the general public in Quetta city, Pakistan.

OBJECTIVE: Although community practices towards disposal of expired and unused medications vary globally, the phenomenon is neglected specifically in developing countries. We, therefore, aimed to assess the disposal practices of unused and expired pharmaceuticals among the general public in Quetta city, Pakistan.
METHODS: A questionnaire-based, cross-sectional survey was conducted among 830 respondents in Quetta city, Pakistan. A pre-validated, structured questionnaire was used for data collection. Data were coded and analyzed by Statistical Package for Social Science (SPSS) version 26. Both descriptive and inferential statistics were sued and p<0.05 was taken as significant.
RESULTS: Almost 87% of the respondents had unused medicines at their homes and reusing the medications was the purpose of medicine storage (50%). Medicines were mostly kept in refrigerators (36.0%) followed by bedrooms (28.8%). Fifty percent of the respondents never checked the expiry date before using the medications. The procedure to dispose of nearly expired or expired medicines was unknown to 88% of the respondents and for those reasons, medicines were disposed either in household trash or flushed in the toilet or sink. Interestingly, medicines were kept at home even after being expired by 27% of the respondents. Income was associated with reason of storing medicines (p = 0.004; φc = 0.402) while educational status had significant associations with storage of medications (p = 0.002; φc = 0.399), reading about storage instructions (p = 0.008; φc = 0.452) and checking expiry date before purchasing and using the medicines (p = 0.007; φc = 0.114 and p = 0.001; φc = 0.100) respectively.
CONCLUSION: Improper storage and disposal of unused and expired medications is a common practice among study respondents and raised serious concerns. Findings of the current study call upon immediate development and implementation of the strategies to promote awareness and strengthen the pharmaceutical waste management program at the societal level.

Background

In recent decades, the increased prevalence of both acute and chronic medical conditions has increased medicine usage. Even though pharmaceutical use is on the rise, it is reported that patients do not consume their medications and such unused medicines are stored in households [1, 2]. Additionally, in clinical practice, 50% of the medications are prescribed irrationally and that results in the redundant storage of medicines causing further harm to the patients as well as the environment [3]. The World Health Organization also revealed that as patients do not use their medicines regularly, their related friends and families are often in contact with medications and can utilize those in time of need without a professional consultation [4]. Moreover, with the worry of unused pharmaceuticals, expired medicines in the possessions of the public are another grave concern. Unfortunately, the safe disposal of such medicines is poorly practiced in societies [4].

The existence of unused or expired pharmaceuticals in homes always places an awaiting hazard. The intentional or unintentional use of expired medicines is not only lethal for humans but is also dangerous to the atmosphere [5-7]. Within this context, expired medicines are often trashed in normal bins or are discarded in sewerage and this incidence when added to the spillways or drinking water places a serious threat to the normal fauna and flora [3]. A classic example of such obliteration is the development of renal failure among vultures. On investigation, it was revealed that carcasses were contaminated with Diclofenac Sodium resulting in the development of kidney-related issues among scavengers [8]. Besides, the traces of Ethinyl Estradiol in water resulted in blight sexual growth and the feminization of marine life [9]. Other than pathological issues, Bashaar et al reported that offshoots after a vaccination movement when disposed of in a local facility caused contagious and physical injuries to the people looking for useful things in the trash [3]. Therefore, in recent years, this issue has caught the serious attention of the policymakers, civil activists, and other health and environmental agencies [10].

In terms of medicine management, it was reported that many of the healthcare facilities in developing countries either lack ignition capability or do not have a waste management system [11, 12]. Keeping the situation in view, WHO came up with an agenda to develop standard operating procedures (SOPs) to address the issues of waste management in the developing world [13]. However, even today, most of the countries do not have SOPs for the clearance of unwanted and fallow pharmaceuticals. Specifically talking about Pakistan, the Drug Regulatory Authority (DRAP) is held conscientious for the proficient scrutinization and assessment of medicine use in the country. Notwithstanding, these policies are weakly implemented and have deficits, and in general the medicine dumping is considered dysfunctional. Possible reasons for this unfortunate management are deficient resources, corruption, and poor accomplishment of governmental rules & regulations. Therefore, in addition to policy implementation, understanding this issue by the public is equally important. Based on our review, we were unable to find any study that focused on expired medicine management in Balochistan, and no information is accessible about the clearance information of run-out pharmaceuticals in Quetta city. Hence, in the light of the above discussion, it is evident that the practices of the general population towards medicine disposal should be addressed. Therefore, the current study is aimed to assess the dumping of unused and run-out medicines among the common population in Quetta city, Pakistan.

Methods

Study design and settings

This was a questionnaire-based, cross-sectional assessment. Data were collected from patients attending the general outpatient departments (OPDs) of Sandeman Provincial Hospital, Quetta (SPHQ). Located in the center of the city, SPHQ was established in 1939. It is a tertiary public care, teaching, and government hospital and is an institute of choice for most of the population [14].

Study population, criteria, and sampling

Eligible participants were adults aged 18 or over, and of either gender visiting SPHQ for treatment or consultation were approached. Consenting to participate and an understanding of Urdu (lingua franca of Pakistan) was needed by the respondents. However, immigrants from other countries and with mental impairments were excluded. Proportionate-based sampling with a double design effect method was employed for sample size calculation and 830 respondents were needed that were approached conveniently for data collection [15].

n = Z2 x p (1-p) / d2 x DEFF;

n = 1.962 x 0.50 (1–0.50) / 0.052 x 2

n = 754 x 0.10 (drop out) = 830

Study instrument and validation

We did a thorough review of the literature and developed the initial version of the questionnaire in the English language [3, 6, 16–18]. In addition to the demographic information, the questionnaire assessed knowledge and practices towards unused and expired medicines. The forward-backward method was used to translate the questionnaire into Urdu by bilingual experts [19]. The internal consistency (α = 0.850) was established through Cronbach’s alpha test [20]. For face and content validity, the questionnaire was reviewed by experts and pretested on 15 respondents [21]. Minor changes were highlighted during the pilot phase and the questionnaire was made available for the principal study (S1 File). Data from the pilot phase was not utilized afterward.

Data collection and analysis

Data were collected from patients attending the outpatient department (OPD) of the Sandeman Provincial Hospital (SPH) Quetta, Pakistan. Data were coded and added to SPSS v 26.0 for analysis. Based on the objectives of the study, descriptive analysis was conducted initially. Relationships were observed by Chi-Square test and Phi / Cremer were used for interpretation where applicable. For all analyses, p<0.05 was considered significant.

Ethical approval

The Advanced Study and Research Board, University of Balochistan, Quetta approved the study. Permission was also taken from the Medical Superintendent of SPHQ. Written informed consent was obtained from all the respondents. Participation in this research was voluntary and the identity was kept confidential.

Results

Demographic profile of the study respondents

Eight hundred and thirty responded to the study with a mean age of 31.31 ± 10.25 years. The gender distribution was almost equal (50%), while 46.6% had a higher secondary level of education. Eighty-three percent of the medications were purchased over the counter while 65.3% were purchased through prescription (Table 1).

Table 1

Demographic profile of the study respondents.

Characteristics	Frequency (N)	Percentage (%)
Age (31.31±10.25)
18–27	370	44.6
28–37	223	26.9
38–47	150	18.1
>47	87	10.5
Gender
Male	409	49.3
Female	421	50.7
Marital status
Married	417	50.2
Unmarried	413	49.8
Locality
Rural	422	50.8
Urban	408	49.2
Education
Secondary	338	40.7
Higher secondary	387	46.6
Graduate	105	12.6
Occupation
Unemployed	251	30.2
Housewife	311	37.4
Public employee	199	23.9
Business	69	8.3
Income *
None	562	67.7
> 20000	92	11.0
20001–40000	95	11.4
> 40000	81	9.7

*Pakistan Rupees

Storage, and disposal practices of unused medicines

Almost 87% of the respondents had unused medicines at their homes and reusing the medications was the purpose of medicine storage (50%). Most of the respondents read storage instructions on the labels and were aware of the storage methods. Medicines were mostly kept in refrigerators (36.0%) followed by bedrooms (28.8%). Only 55 respondents disposed of unused medications at their homes and trash cans (dustbins) were used by most respondents for disposal of unused medicines (Table 2).

Table 2

Storage, and disposal practices of unused medicines.

Items	Frequency	Percentage
Do you currently have any unused medicines stored at home?
Yes	719	86.6
No	111	13.4
Why do you keep unused medicines at home?
Can reuse the medicine	415	50.0
Medicine is needed in an emergency	356	42.8
Can be used by friends or family members	59	7.2
Do you know how to store medicines at home?
Yes	625	75.3
No	205	24.7
Do you read storage instructions on the labels/leaflets?
Yes	657	79.1
No	173	20.9
Where do you store your unused medicine?
Kitchen cabinet	178	21.4
Bathroom cabinet	85	10.2
Bedroom cabinet	245	28.8
Medicine box	23	2.77
Refrigerator	299	36.0
Do you dispose of unused medicines stored at your home?
Yes	55	6.7
No	775	93.3
How do you dispose of unused medicines stored at your home? *
The exchange at the pharmacies	10	18.1
Throw away in dustbins (household trash)	32	58.1
Give to hospitals/clinic	5	9.0
Give to friends or relatives	8	14.5

*Response out of 55

Practices and disposal of expired medicines

The practices and disposal of expired medicines are presented in Table 3. Most of the respondents (94.9%) checked the expiry date before procuring the medicines. However, nearly 50% never checked the expiry date before using the medications. The procedure to dispose of nearly expired or expired medicines was unknown to 88% of the respondents and for those reasons, medicines were disposed of either in household trash or flushed in the toilet or sink. Intriguingly, medicines were kept at home even after being expired by 27% of the respondents.

Table 3

Practices and disposal of expired medicines.

Items	Frequency	Percentage
Do you check the expiry date of the medicines before purchasing?
Yes	788	94.9
No	42	5.0
Do you check the expiry date before using the medicines?
Yes	405	48.7
No	425	51.3
Do you know the procedure to dispose of nearly expired medicines?
Yes	98	11.8
No	732	88.2
How do you dispose of nearly expired medicines?
Donte to hospital/clinic	85	10.2
Return it to pharmacies	61	7.3
Throw away in dustbins (household trash)	312	37.5
Flush in toilet or sink	301	36.2
Give them to friends/family members/ others	41	4.9
Keep at home until expired	30	3.6
Do you know the procedure to dispose of expired medicines?
Yes	98	11.8
No	732	88.2
How do you dispose expired medicines?
Throw away in dustbins (household trash)	354	42.6
Flush in toilet or sink	212	25.5
Return them to pharmacies or hospitals for disposal	37	4.4
No action (keep at home)	227	27.3

Association between storage, and disposal practices of unused medicines and demographics

A significant association with moderate association (p<0.05; φc = 0.402) was reported when the reasons for storing medicines were compared with income. Accordingly, education was also reported to have significant associations with the storage of medications and reading about storage instructions (p<0.05). For both significant associations, the effect size was also moderate (φc = 0.399 & 0.452 respectively). No association was reported for other variables as shown in Table 4.

Table 4

Association between storage, and disposal practices of unused medicines and demographics.

Items	P-Value*
	Age	Gender	Status	Locality	Education	Occupation	Income
Do you currently have any unused medicines stored at home?	0.254	0.554	0.411	0.091	0.177	0.488	0.288
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A
Why do you keep unused medicines at home?	0.335	0.129	0.277	0.377	0.590	0.600	0.004
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = 0.402
Do you know how to store medicines at home?	0.399	0.445	0.519	0.148	0.002	0.272	0.516
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = 0.399	φc = N/A	φc = N/A
Do you read storage instructions on the labels/leaflets?	0.088	0.200	0.551	0.199	0.008	0.126	0.500
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = 0.452	φc = N/A	φc = N/A
Where do you store your unused medicine?	0.700	0.177	0.622	0.410	0.224	0.177	0.100
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A
Do you dispose of unused medicines stored at your home?	0.118	0.514	0.418	0.841	0.281	0.547	0.109
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A
How do you dispose of unused medicines stored at your home?	0.091	0.065	0.557	0.074	0.300	0.099	0.058
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A

*Chi-Square test; Bold values represent significant associations

Note: φc = Phi/Cramer’s V; N/A = Not applicable

Association between practices and disposal of expired medicines and demographics

The association between practices and disposal of expired medicines and demographics is reported in Table 5. As in Table 4, education was significantly associated with checking the expiry date of medicines before procurement as well as before using them. Weak effect size was reported for both variables (φc = 0.114 & 0.100 respectively). No association was reported for other variables Table 5.

Table 5

Association between storage, and disposal practices of expired medicines and demographics.

Items	P-Value*
	Age	Gender	Status	Locality	Education	Occupation	Income
Do you check the expiry date of the medicines before purchasing?	0.149	0.775	0.249	0.089	0.007	0.600	0.177
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = 0.114	φc = N/A	φc = N/A
Do you check the expiry date before using the medicines?	0.559	0.250	0.320	0.706	0.001	0.735	0.553
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = 0.100	φc = N/A	φc = N/A
Do you know the procedure to dispose of nearly expired medicines?	0.104	0.261	0.180	0.200	0.280	0.572	0.516
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A
How do you dispose of nearly expired medicines?	0.338	0.419	0.447	0.109	0.119	0.422	0.408
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A
Do you know the procedure to dispose of expired medicines?	0.574	0.077	0.122	0.240	0.310	0.470	0.283
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A
How do you dispose of expired medicines?	0.630	0.931	0.149	0.801	0.411	0.099	0.142
	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A	φc = N/A

*Chi-Square test; Bold values represent significant associations

Note: φc = Phi/Cramer’s V; N/A = Not applicable

Discussion

Medicines are generally classified based on similarities. The most used criterion is the pharmacological class that further subdivides medicines based on the mode of action, the physiologic effects of the medicines and chemical structure [22]. According to the Food and Drug Administration (FDA), the best option of managing unused or expired medicines is to find a drug take-back location. Normally, the take-back location is a local pharmacy or a hospital. These facilities offer on-site medicine drop-off boxes, mail-back programs, or in-home disposal products. The other option in the absence of a take-back location is checking the FDA’s Flush List. However, if the medicines are not in the Flush List, FDA recommends disposing the medicine in trash before mixing them with unappealing substance such as dirt or cat litter. Medicines should not be crushed, and the mixture should be placed in a sealed plastic bag before disposing into the trash [23].

For decades, managing medicines (stored, unused, and expired) have received the attention of both healthcare professionals and social scientists. Additionally, with the increased frequency of diseases, medicines used around the globe has immensely increased. The IQVIA Institute for Human Data Science reported an increase of 3% compound annual growth rate in medicine use since 2014, and a projected increase of 2–5% of global spending on medications [24]. Although there is no specific data available from Pakistan on medicine expenditure, total health expenditure in 2017–18 reported an increase of 31.3% when compared with 2015–2016. It is pertinent to mention here that this increase is for direct health expenditures, and excludes health-related expenditures on training, research, and environmental health [25]. With such an enormous increase in healthcare system utilization, quality management of medicines always remains debatable [3]. Medicine management is a highly debatable topic around the globe [26-28], however, data from Pakistan is limited in literature and is reported from metropolitan areas of the country [18, 29, 30]. There is a paucity of information from remote areas of the country and for that reason, the current study was undertaken. To the best of our knowledge, this is the first study from Baluchistan (Quetta city), the largest of the provinces of Pakistan.

Possession of unused medicines was prevalent from the study findings that are in line with what is reported from studies of the same nature [3, 31]. On the contrary, where reusing the medicines was the reason for storage, literature has reported conflicting results [32, 33]. A possible explanation of this difference is related to the limitations faced by the healthcare system of Pakistan. Where inpatients are provided with ample facilities, outpatients must procure their medicines as public hospitals do not provide medicines to them. Medicine prices in the last years have increased considerably [34] and therefore most of the patients keep the unused medicines because of affordability issues. However, storing unused medicines does promote medicine exchange leading to self-medication which is a common practice in developing countries hence leading to absurd medicine use [31].

Refrigerators were used for medicine storage followed by bedroom cabinets (Table 2). As frequently reported in the literature [31, 33, 35, 36], both unused and expired medicines in the current study were also disposed either in dustbins or flushed into the sinks or toilets. Such practices are associated with ecological hazards that lead to a variety of concerns including antimicrobial resistance, damage to the aquatic environment, and injurious effects to the community health through drinking water [7]. Specifically in Quetta city where drain water is used for cultivation, this leads to contamination of vegetables and fruits which may contain medications in trace amounts [37, 38]. Even though the city has an advanced water treatment technology system, it is often unfunctional because of a lack of operational funding [39]. Disposing medicines in Quetta city is a challenge that needs priority attention to minimize the harmful effects caused by the addition of medicines in the environment. Even when the water is treated, most of the pharmaceutical compounds can enter water supply because conventional wastewater system fails to eliminate the pharmaceutical compounds completely [40]. Humans are directly affected by such compounds as oxidative stress is initiated through the consumption of untreated water. Various studies have revealed that oxidative stress is responsible for onset or progression of several diseases like atherosclerosis, metabolic disorders, cardiovascular diseases, diabetes, and cancer [41]. Free radicals are formed directly in response to oxidizing pollutants and results in oxidative stress that produces potential harm as discussed in literature [42].

Correlating our discussion, poor disposal practices in the current study are associated with a lack of information. The participants had no information on medicine disposal and that led to take uninformed decisions in disposing of their medications. For us, this is not surprising as pharmacies in Pakistan follow a business model and are not patient-oriented [43]. Furthermore, healthcare professionals (physicians and pharmacists) also pay the least attention to patient education and counseling. Lastly, little information is passed to the public by authorities (DRAP) on the disposal of unused or expired drugs that altogether complicates the issue. Our observations are supported by literature and the lack of information on medicine disposal methods is recorded from different countries [3, 31, 44].

While discussing the associations, education was found to be significantly related and the interpretation is relatively straightforward. Education plays a key role in developing the importance of medicines and treatment regimens, rational utilization of healthcare services, and an understanding of the needs and demands of pharmaceutical care [45]. Furthermore, education also maximizes the opportunity to exercise better control over the treatment regimens and disease conditions [46]. Within this context, Raghupathi & Raghupathi in their empirical assessment identified associations between education and health indicators. The authors targeted 26 OECD countries and data of 20 years (1995–2015) was analyzed [47]. It was concluded that people with higher educational achievement had better health and lifespans compared to less educated. Among all levels, tertiary education was critical and rated as an influencing factor. Therefore, the relationship of education is not surprising as educated people tend to read more about their diseased conditions, the medications they are using, and the methods while storing or dealing with unused or expired medicines.

Income was also significantly associated with the reason for storing medicines. We must remember that Pakistan faces a huge crisis when it comes to efficient and effective utilization of resources. Only 1.2% of the GDP is spent on health [48] and most of the expenses incurred during diagnosis, treatment, and management of diseases by the patients are out of pocket [49]. Besides, Pakistan’s fragile economy was badly affected by COVID-19 and long-term effects increased unemployment because various sectors are still in crisis. Medicine prices in Pakistan have seen an increase of almost 300% in the last two years (highest in 40 years) and thus affordability of medicines for low-income earners is a grave concern [50]. With an increase in recession and poverty index, this seems to be a decent reason to store medicines to be reused. However, storing medicines has its limitations and this should be discouraged by the healthcare professionals while having interactions with their patients. Nevertheless, the conditions will remain the same until the Government of Pakistan starts investing in healthcare sector of Pakistan and show serious efforts in resolving the issues of medicine affordability in Pakistan.

An overwhelming finding of the current study revealed that 27% of the respondents kept expired medicines at their homes (Table 3). We must remember that storing expired medicines at homes may result in intentional or accidental consumption which can result in a health crisis [30]. Moreover, consuming expired medicines cause more serious illnesses because of change in chemical composition [51]. Keeping expired medicines at home is relatable to poor knowledge regarding safe disposal practices. Within this context, the guidelines proposed by internal agencies are intended for national authorities (DRAP in the case of Pakistan) and the least attention is given to household levels [52]. To circumvent a health crisis, there is an urgent need for a well-designed public education program focusing on medicine storage and disposal of expired medicines in Quetta city, Pakistan.

Conclusion

Improper storage and disposal of unused and expired medications is a common practice among study respondents and raised serious concerns. Addressing this issue needs a coordinated and systematic public awareness campaigns initiated by DRAP to address the negative risks of unused and expired medicines. This will help in promoting reliable practices that will be beneficial for the society and healthcare system.

Strengths and limitations

Storage and disposal practices of unused and expired medicines are reported for the first time from Quetta city, Pakistan. However, the study findings are not generalized and consequently a large-scale study is recommended to highlight storage and disposal practices of unused and expired medicines at a large scale.

Recommendations

We do agree that comprehensive information was retrievable from the respondents which was unexplored in the current study. To get an in-depth knowledge on unused and expired medicines, a home-based study is hereby recommended. This will exactly present the types and quantity of unused and expired medicines that will be in possession of the study respondents. This will also help in assessing the cost incurred and its effect on the demographics as well as on the society.

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Reviewer #1: The authors assessed the current disposal of unused and used up medicines by the general public in Quetta, Pakistan by means of a questionnaire, a typical but forgotten social health problem currently faced by the public.

1 Suggest some feasible measures for the management of expired drugs.

2 It is suggested to classify the types of drugs before investigating the disposal.

Reviewer #2: φc was reported in the paper. Whereas，originnal φc data was not supplied in the Tables. Could you provide them?

The average age of the responders was 31. No enough aging population was included. Dose the age distribution in the questionnaire survey idetified with population distribution of Pakistan?

More information could be collected, such as variety of the medicines unused and expired pharmaceuticals among the general public. These data should be valuable for policy setting.

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3 Apr 2022

We are thankful to the editorial team of PLOS One for considering our manuscript. All queries of the reviewers are answered and a rebuttal is attached with the submission.

Submitted filename: Response to reviewers.docx

Click here for additional data file.

25 Apr 2022

Disposal practices of unused and expired pharmaceuticals among the general public in Quetta city, Pakistan

PONE-D-22-00011R1

Dear Dr. Bashaar,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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Kind regards,

Hongxun Tao

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #3: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions?

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Reviewer #1: Yes

Reviewer #3: (No Response)

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #3: (No Response)

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Reviewer #1: Yes

Reviewer #3: (No Response)

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Reviewer #1: Yes

Reviewer #3: (No Response)

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Reviewer #1: The authors assessed the dumping of unused and run-out 128 medicines among the common population in Quetta city, Pakistan. The results are interesting.

Reviewer #3: NO COMMENT IN THIS VERSION, THE AUTHOR HAVE REVISED THE MANUSCRIPT WELL, I SUGGEST TO ACCEPT THIS PAPER IN ITS PRESENT FORM

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Reviewer #1: No

Reviewer #3: No

29 Apr 2022

PONE-D-22-00011R1

Disposal practices of unused and expired pharmaceuticals among the general public in Quetta city, Pakistan

Dear Dr. Bashaar:

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

If we can help with anything else, please email us at plosone@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Hongxun Tao

Academic Editor

PLOS ONE