Arthur Cassa Macedo1, Luciano Inácio Mariano1,2, Marina Isoni Martins2, Clarisse Vasconcelos Friedlaender1, Jesus Mística Ventura1,3, João Victor de Faria Rocha4, Sarah Teixeira Camargos2,3,5, Francisco Eduardo Costa Cardoso2,3,5, Paulo Caramelli1,2,5, Leonardo Cruz de Souza1,2,5. 1. Grupo de Neurologia Cognitiva e do Comportamento, Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG Brazil. 2. Programa de Pós-Graduação em Neurociências Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG Brazil. 3. Ambulatório de Distúrbios de Movimento do Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG Brazil. 4. Departamento de Psicologia, Faculdade de Filosofia e Ciências Humanas Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG Brazil. 5. Departamento de Clínica Médica, Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG Brazil.
Abstract
Background: Progressive supranuclear palsy (PSP) is the most common atypical parkinsonism and has executive dysfunction as a core feature. The magnitude of episodic memory disturbance in PSP is yet to be clarified. Objectives: To investigate how impaired is episodic memory in PSP compared to healthy controls and other neuropsychiatric disorders. Also, we sought to identify the brain correlates underlying these memory disturbances. Methods: We performed a systematic search on PubMed and Scopus, combining the terms "progressive supranuclear palsy" AND "memory". The search was limited to papers published in English, French, Portuguese or Spanish, with no chronological filters. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results: The initial search returned 464 results. After extraction of duplicates, 356 records were screened, leading to inclusion of 38 studies. Most studies found that PSP patients had lower scores on episodic memory compared to healthy controls. In addition, the majority of studies suggest that PSP does not differ from Parkinson's disease and from atypical parkinsonism in terms of episodic memory performance. The same is seen for PSP and frontotemporal dementia. Conversely, episodic memory impairment seems to be greater in typical Alzheimer's disease compared to PSP. Neuroimaging findings indicate that striatofrontal structures may be involved in PSP episodic memory dysfunction, while no associations with mesial structures (including hippocampi) were found. Conclusions: Episodic memory is impaired in PSP. Whether this amnesia refers to executive dysfunction is still controversial. More studies are warranted to clarify the neural basis of memory impairment in PSP.
Background: Progressive supranuclear palsy (PSP) is the most common atypical parkinsonism and has executive dysfunction as a core feature. The magnitude of episodic memory disturbance in PSP is yet to be clarified. Objectives: To investigate how impaired is episodic memory in PSP compared to healthy controls and other neuropsychiatric disorders. Also, we sought to identify the brain correlates underlying these memory disturbances. Methods: We performed a systematic search on PubMed and Scopus, combining the terms "progressive supranuclear palsy" AND "memory". The search was limited to papers published in English, French, Portuguese or Spanish, with no chronological filters. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results: The initial search returned 464 results. After extraction of duplicates, 356 records were screened, leading to inclusion of 38 studies. Most studies found that PSP patients had lower scores on episodic memory compared to healthy controls. In addition, the majority of studies suggest that PSP does not differ from Parkinson's disease and from atypical parkinsonism in terms of episodic memory performance. The same is seen for PSP and frontotemporal dementia. Conversely, episodic memory impairment seems to be greater in typical Alzheimer's disease compared to PSP. Neuroimaging findings indicate that striatofrontal structures may be involved in PSP episodic memory dysfunction, while no associations with mesial structures (including hippocampi) were found. Conclusions: Episodic memory is impaired in PSP. Whether this amnesia refers to executive dysfunction is still controversial. More studies are warranted to clarify the neural basis of memory impairment in PSP.
Authors: Béatrice Garcin; Emmanuelle Volle; Aurélie Funkiewiez; Bruce L Miller; Bruno Dubois; Richard Levy Journal: Neuropsychologia Date: 2018-06-26 Impact factor: 3.139
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Authors: Richard G Brown; Lucette Lacomblez; Bernard G Landwehrmeyer; Thomas Bak; Ingo Uttner; Bruno Dubois; Yves Agid; Albert Ludolph; Gilbert Bensimon; Christine Payan; Nigel P Leigh Journal: Brain Date: 2010-06-24 Impact factor: 13.501
Authors: Günter U Höglinger; Gesine Respondek; Maria Stamelou; Carolin Kurz; Keith A Josephs; Anthony E Lang; Brit Mollenhauer; Ulrich Müller; Christer Nilsson; Jennifer L Whitwell; Thomas Arzberger; Elisabet Englund; Ellen Gelpi; Armin Giese; David J Irwin; Wassilios G Meissner; Alexander Pantelyat; Alex Rajput; John C van Swieten; Claire Troakes; Angelo Antonini; Kailash P Bhatia; Yvette Bordelon; Yaroslau Compta; Jean-Christophe Corvol; Carlo Colosimo; Dennis W Dickson; Richard Dodel; Leslie Ferguson; Murray Grossman; Jan Kassubek; Florian Krismer; Johannes Levin; Stefan Lorenzl; Huw R Morris; Peter Nestor; Wolfgang H Oertel; Werner Poewe; Gil Rabinovici; James B Rowe; Gerard D Schellenberg; Klaus Seppi; Thilo van Eimeren; Gregor K Wenning; Adam L Boxer; Lawrence I Golbe; Irene Litvan Journal: Mov Disord Date: 2017-05-03 Impact factor: 10.338
Authors: M Klietz; T Schnur; S Drexel; F Lange; A Tulke; L Rippena; L Paracka; D Dressler; G U Höglinger; F Wegner Journal: Parkinsons Dis Date: 2020-02-24