| Literature DB >> 35584955 |
Kento Iwai1,2, Khimiya Wada1, Feiyue Hao1,3, Haruyasu Asahara1,2,4, Nagatoshi Nishiwaki1,2.
Abstract
Direct aziridination of a nitrostyrene is achieved upon treatment with an alkylamine and N-chlorosuccinimide. The reaction is initiated by the Michael addition of amine to nitroalkene. Subsequent N-chlorination and nucleophilic substitution at the nitrogen atom afford 1-alkyl-2-nitroaziridine diastereoselectively. This reaction mechanism was clarified by NMR studies.Entities:
Keywords: chloramine; intramolecular nucleophilic substitution; nitroalkene; nitroaziridine
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Year: 2022 PMID： 35584955 DOI： 10.5650/jos.ess21406
Source DB: PubMed Journal: J Oleo Sci ISSN： 1345-8957 Impact factor: 1.601