Literature DB >> 35584006

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma.

Daniel R Schmidt1,2,3, Julia E Heyman1, James P O'Brien1, Amy C Liu1, Shawn M Davidson1,4,2, William J Israelsen1,4, Talya L Dayton1,4, Raghav Sehgal5, Roderick T Bronson1, Elizaveta Freinkman6, Howard H Mak1, Giuseppe Nicolò Fanelli7,8, Scott Malstrom1, Gary Bellinger1,3, Arkaitz Carracedo3, Pier Paolo Pandolfi3, Kevin D Courtney9, Abhishek Jha5, Ronald A DePinho9, James W Horner9, Craig J Thomas10, Lewis C Cantley3,7, Massimo Loda7,9, Matthew G Vander Heiden1,4,2,9.   

Abstract

SIGNIFICANCE: Differential expression of PKM1 and PKM2 impacts prostate tumorigenesis and suggests a potential therapeutic vulnerability in prostate cancer. ©2022 The Authors; Published by the American Association for Cancer Research.

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Year:  2022        PMID： 35584006      PMCID： PMC9256808          DOI： 10.1158/0008-5472.CAN-21-2352

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   13.312


  69 in total

Review 1.  The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy.

Authors:  L C Costello; R B Franklin
Journal:  Oncology       Date:  2000-11       Impact factor: 2.935

2.  A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo.

Authors:  J Zhang; T Z Thomas; S Kasper; R J Matusik
Journal:  Endocrinology       Date:  2000-12       Impact factor: 4.736

3.  Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.

Authors:  Rachael F Grace; Christian Rose; D Mark Layton; Frédéric Galactéros; Wilma Barcellini; D Holmes Morton; Eduard J van Beers; Hassan Yaish; Yaddanapudi Ravindranath; Kevin H M Kuo; Sujit Sheth; Janet L Kwiatkowski; Ann J Barbier; Susan Bodie; Bruce Silver; Lei Hua; Charles Kung; Peter Hawkins; Marie-Hélène Jouvin; Chris Bowden; Bertil Glader
Journal:  N Engl J Med       Date:  2019-09-05       Impact factor: 91.245

4.  A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

Authors:  Joanna Kaplon; Liang Zheng; Katrin Meissl; Barbara Chaneton; Vitaly A Selivanov; Gillian Mackay; Sjoerd H van der Burg; Elizabeth M E Verdegaal; Marta Cascante; Tomer Shlomi; Eyal Gottlieb; Daniel S Peeper
Journal:  Nature       Date:  2013-05-19       Impact factor: 49.962

Review 5.  Inside and out: the activities of senescence in cancer.

Authors:  Pedro A Pérez-Mancera; Andrew R J Young; Masashi Narita
Journal:  Nat Rev Cancer       Date:  2014-07-17       Impact factor: 60.716

Review 6.  The redox requirements of proliferating mammalian cells.

Authors:  Aaron M Hosios; Matthew G Vander Heiden
Journal:  J Biol Chem       Date:  2018-01-16       Impact factor: 5.157

7.  M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.

Authors:  Marta Cortés-Cros; Christelle Hemmerlin; Stephane Ferretti; Juan Zhang; John S Gounarides; Hong Yin; Alban Muller; Anne Haberkorn; Patrick Chene; William R Sellers; Francesco Hofmann
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-24       Impact factor: 11.205

8.  Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.

Authors:  Shunyou Wang; Jing Gao; Qunying Lei; Nora Rozengurt; Colin Pritchard; Jing Jiao; George V Thomas; Gang Li; Pradip Roy-Burman; Peter S Nelson; Xin Liu; Hong Wu
Journal:  Cancer Cell       Date:  2003-09       Impact factor: 31.743

9.  FDG-PET/CT for pre-operative staging and prognostic stratification of patients with high-grade prostate cancer at biopsy.

Authors:  Jean-Mathieu Beauregard; Annie-Claude Blouin; Vincent Fradet; André Caron; Yves Fradet; Claude Lemay; Louis Lacombe; Thierry Dujardin; Rabi Tiguert; Goran Rimac; Frédérick Bouchard; Frédéric Pouliot
Journal:  Cancer Imaging       Date:  2015-03-03       Impact factor: 3.909

10.  Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

Authors:  Talya L Dayton; Vasilena Gocheva; Kathryn M Miller; Arjun Bhutkar; Caroline A Lewis; Roderick T Bronson; Matthew G Vander Heiden; Tyler Jacks
Journal:  Cancer Metab       Date:  2018-05-31
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  1 in total

1.  β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel.

Authors:  Hannah R Foster; Thuong Ho; Evgeniy Potapenko; Sophia M Sdao; Shih Ming Huang; Sophie L Lewandowski; Halena R VanDeusen; Shawn M Davidson; Rebecca L Cardone; Marc Prentki; Richard G Kibbey; Matthew J Merrins
Journal:  Elife       Date:  2022-08-23       Impact factor: 8.713
  1 in total

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