Guan-Yeu Chen1,2, Teh-Fu Hsu3,4,5, I-San Chan1,2, Chia-Hao Liu1,2,5,6, Wei-Ting Chao1,2,5,6, Ying-Chu Shih1,2, Ling-Yu Jiang1,2,5,6, Yen-Hou Chang1,2,5,6, Peng-Hui Wang1,2,5,6,7,8, Yi-Jen Chen9,10,11,12. 1. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan. 2. Department of Obstetrics and Gynecology, National Yang Ming Chiao Tung University, Taipei, Taiwan. 3. Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. 4. College of Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan. 5. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. 6. Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. 7. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. 8. The Female Cancer Foundation, Taipei, Taiwan. 9. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan. chenyj@vghtpe.gov.tw. 10. Department of Obstetrics and Gynecology, National Yang Ming Chiao Tung University, Taipei, Taiwan. chenyj@vghtpe.gov.tw. 11. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. chenyj@vghtpe.gov.tw. 12. Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. chenyj@vghtpe.gov.tw.
Abstract
OBJECTIVE: This study aimed to compare the ability of the O-RADS and ADNEX models to classify benign or malignant adnexal lesions. METHODS: This retrospective single-center study included women who underwent surgery for adnexal lesions. Two gynecologists independently categorized the adnexal lesions according to the O-RADS and ADNEX models. Four additional readers were included to validate the new quick-access O-RADS flowchart. RESULTS: Among the 322 patients included in this study, 264 (82.0%) had a benign diagnosis, and 58 (18.0%) had a malignant diagnosis. The malignant rates of O-RADS 2, O-RADS 3, O-RADS 4, and O-RADS 5 were 0%, 3.0%, 37.7%, and 78.9%, respectively. The AUC of the O-RADS in the 322 patients was 0.93. On comparing the O-RADS and ADNEX models in the remaining 281 patients, the AUCs of the O-RADS, ADNEX model with CA125, and ADNEX model without CA125 were 0.92, 0.95, and 0.94, respectively. When setting a uniform cutoff of ≥ 10% (≥ O-RADS 4) to predict malignancy, the O-RADS had higher sensitivity than the ADNEX model (96.6% vs. 91.4%), and relatively similar specificity. In addition, the readers with the quick-access flowchart spent less time categorizing O-RADS than the readers with only the original O-RADS table (mean analysis time: 99 min 15 s vs. 111 min 55 s). CONCLUSIONS: The O-RADS classification of the adnexal lesions as benign or malignant was comparable to that of the ADNEX model and had higher sensitivity at the 10% cutoff value. A quick-access O-RADS flowchart was helpful in O-RADS categorization and might shorten the analysis time. KEY POINTS: • Both O-RADS and ADNEX models had good diagnostic performance in distinguishing adnexal malignancy, and O-RADS had higher sensitivity than ADNEX model in uniform 10% cutoff to predict malignancy. • Quick-access O-RADS flowchart was developed to help review O-RADS classification and might help reduce the analysis time.
OBJECTIVE: This study aimed to compare the ability of the O-RADS and ADNEX models to classify benign or malignant adnexal lesions. METHODS: This retrospective single-center study included women who underwent surgery for adnexal lesions. Two gynecologists independently categorized the adnexal lesions according to the O-RADS and ADNEX models. Four additional readers were included to validate the new quick-access O-RADS flowchart. RESULTS: Among the 322 patients included in this study, 264 (82.0%) had a benign diagnosis, and 58 (18.0%) had a malignant diagnosis. The malignant rates of O-RADS 2, O-RADS 3, O-RADS 4, and O-RADS 5 were 0%, 3.0%, 37.7%, and 78.9%, respectively. The AUC of the O-RADS in the 322 patients was 0.93. On comparing the O-RADS and ADNEX models in the remaining 281 patients, the AUCs of the O-RADS, ADNEX model with CA125, and ADNEX model without CA125 were 0.92, 0.95, and 0.94, respectively. When setting a uniform cutoff of ≥ 10% (≥ O-RADS 4) to predict malignancy, the O-RADS had higher sensitivity than the ADNEX model (96.6% vs. 91.4%), and relatively similar specificity. In addition, the readers with the quick-access flowchart spent less time categorizing O-RADS than the readers with only the original O-RADS table (mean analysis time: 99 min 15 s vs. 111 min 55 s). CONCLUSIONS: The O-RADS classification of the adnexal lesions as benign or malignant was comparable to that of the ADNEX model and had higher sensitivity at the 10% cutoff value. A quick-access O-RADS flowchart was helpful in O-RADS categorization and might shorten the analysis time. KEY POINTS: • Both O-RADS and ADNEX models had good diagnostic performance in distinguishing adnexal malignancy, and O-RADS had higher sensitivity than ADNEX model in uniform 10% cutoff to predict malignancy. • Quick-access O-RADS flowchart was developed to help review O-RADS classification and might help reduce the analysis time.
Authors: B Van Calster; K Van Hoorde; W Froyman; J Kaijser; L Wynants; C Landolfo; C Anthoulakis; I Vergote; T Bourne; D Timmerman Journal: Facts Views Vis Obgyn Date: 2015
Authors: Julio Vara; Nabil Manzour; Enrique Chacón; Ana López-Picazo; Marta Linares; Maria Ángela Pascual; Stefano Guerriero; Juan Luis Alcázar Journal: Cancers (Basel) Date: 2022-06-27 Impact factor: 6.575