| Literature DB >> 35583582 |
Wen-Xiao Zhao1, Tong Wang1, Ya-Nan Zhang2,3, Qian Chen2,3, Yuan Wang2,3, Yan-Qing Xing1, Jun Zheng1, Chen-Chen Duan1, Li-Jun Chen1, Hai-Jun Zhao4,5, Shi-Jun Wang2,3.
Abstract
The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity, type 2 diabetes mellitus, heart failure, and non-alcoholic fatty liver disease. Polysaccharides extracted from Chinese medicine (CM) can not only alleviate pathological status but also promote health by anti-inflammatory, regulating immunity, lowering blood glucose and lipids, anti-cancer, and anti-oxidation. The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment. In addition, they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota. This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health.Entities:
Keywords: Chinese medicine; gut microbiota; gut-organ axis; lipopolysaccharides; polysaccharides; short-chain fatty acids; synergistic actions
Year: 2022 PMID： 35583582 DOI： 10.1007/s11655-022-3522-y
Source DB: PubMed Journal: Chin J Integr Med ISSN： 1672-0415 Impact factor: 1.978