Literature DB >> 35582553

Abdominal Pain in a Patient With Giant Cell Arteritis.

Tharani Sundararajan1, Krati Chauhan1.   

Abstract

Giant cell arteritis (GCA) is a large vessel vasculitis seen in the elderly. It is primarily treated with corticosteroids, which are known to have a multitude of adverse effects, including predisposition to infection and intestinal diverticular perforation. We describe a unique case of a GCA patient with the subtle presentation of acute abdomen. A 71-year-old woman with GCA on corticosteroids presented with vague abdominal pain at a routine follow-up appointment. Diagnostic workup revealed perforated diverticulitis and urinary tract infection. She was admitted and managed conservatively. Clinicians may encounter similar scenarios to ours in which GCA patients will present with subtle symptoms of an acute abdomen. Corticosteroids mask symptoms in the setting of severe complications, especially in elderly patients. We recommend providers have a high index of suspicion for an acute condition, even when the clinical manifestations are subtle.
Copyright © 2022, Sundararajan et al.

Entities:  

Keywords:  abdominal pain; acute abdomen; giant cell arteritis; glucocorticoids; microperforation

Year:  2022        PMID: 35582553      PMCID: PMC9107380          DOI: 10.7759/cureus.24149

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  6 in total

1.  Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England.

Authors:  Jianhua Wu; Adam Keeley; Christian Mallen; Ann W Morgan; Mar Pujades-Rodriguez
Journal:  CMAJ       Date:  2019-06-24       Impact factor: 8.262

Review 2.  The role of the glucocorticoid receptor in inflammation and immunity.

Authors:  Ulrike Baschant; Jan Tuckermann
Journal:  J Steroid Biochem Mol Biol       Date:  2010-03-24       Impact factor: 4.292

3.  Serious adverse effects associated with glucocorticoid therapy in patients with giant cell arteritis (GCA): A nested case-control analysis.

Authors:  Jessica C Wilson; Khaled Sarsour; Neil Collinson; Katie Tuckwell; David Musselman; Micki Klearman; Pavel Napalkov; Susan S Jick; John H Stone; Christoph R Meier
Journal:  Semin Arthritis Rheum       Date:  2016-11-28       Impact factor: 5.532

4.  Perforated colonic diverticular disease: the importance of NSAIDs, opioids, corticosteroids, and calcium channel blockers.

Authors:  Kristoffer Piekarek; Leif A Israelsson
Journal:  Int J Colorectal Dis       Date:  2008-08-05       Impact factor: 2.571

5.  Incidence of Severe Infections and Infection-Related Mortality During the Course of Giant Cell Arteritis: A Multicenter, Prospective, Double-Cohort Study.

Authors:  J Schmidt; A Smail; B Roche; P Gay; V Salle; H Pellet; P Duhaut
Journal:  Arthritis Rheumatol       Date:  2016-06       Impact factor: 10.995

6.  Steroid-induced sigmoid diverticular perforation in a patient with temporal arteritis: a rare clinical pathology.

Authors:  Bulent Kaya; Orhan Aras; Orhan Bat; Nuriye Esen Bulut; Kemal Memisoglu
Journal:  Clin Med Insights Pathol       Date:  2012-03-29
  6 in total

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