Literature DB >> 3558111

Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus.

I O Kibwage, G Janssen, R Busson, J Hoogmartens, H Vanderhaeghe, L Verbist.   

Abstract

The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13----C11 trans-lactonization. The five compounds have very little antimicrobial activity.

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Year:  1987        PMID： 3558111     DOI： 10.7164/antibiotics.40.1

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

Review 1.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

2.  Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.

Authors:  F T Counter; P W Ensminger; D A Preston; C Y Wu; J M Greene; A M Felty-Duckworth; J W Paschal; H A Kirst
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

3.  Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification.

Authors:  Kai Bao; Weige Zhang; Chuanliang Zhang; Yingwei Qu; Liang Tian; Lan Wu; Xiang Zhao; Maosheng Cheng
Journal:  Molecules       Date:  2007-08-30       Impact factor: 4.411

Review 4.  Engineered polyketides: Synergy between protein and host level engineering.

Authors:  Jesus F Barajas; Jacquelyn M Blake-Hedges; Constance B Bailey; Samuel Curran; Jay D Keasling
Journal:  Synth Syst Biotechnol       Date:  2017-09-07

5.  The Electrospray Ionization - Mass Spectra of Erythromycin A Obtained from a Marine Streptomyces sp. Mutant.

Authors:  A M El-Bondkly; Howaida I Abd-Alla; M Shaaban; K A Shaaban
Journal:  Indian J Pharm Sci       Date:  2008 May-Jun       Impact factor: 0.975
  5 in total

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