Hong Jiang1, Min Fang, Ross Franklin, Ava-Gaye Simms, Zohra Fadli, Jianhua Wang. 1. Bascom Palmer Eye Institute (H.J., M.F., A.-G.S., J.W.), Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL; Department of Neurology (H.J.), University of Miami Miller School of Medicine, Miami, FL; Department of Ophthalmology, Shenzhen Key Laboratory of Ophthalmology (M.F.), Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong, China; and Johnson & Johnson Vision Care, Inc., (R.F., Z.F.) Jacksonville, FL.
Abstract
PURPOSE: To determine associations between lid wiper microvascular responses, lens fit, and comfort after 1 day of contact lens adaptation by neophytes. METHODS: Functional slitlamp biomicroscopy was used to image the microvascular network of the upper tarsal conjunctiva, lid wiper, and bulbar conjunctiva. Fractal dimension was obtained to represent vessel density. Ultra-high-resolution optical coherence tomography was used to image the lens edge and fitting characteristics, including lens movement and lens-induced conjunctival indentation. Ocular comfort was rated using a 50-point visual analogue scale (VAS). Forty-nine healthy subjects without a history of contact lens wear were recruited. A contact lens was then fitted in the right eye. Imaging was taken at baseline and 6 hr after lens wear. RESULTS: The changes of VAS comfort score were negatively related to the changes of the vessel density in the lid-wiper (R 2 =0.18, P =0.002) and bulbar conjunctiva (R 2 =0.13, P =0.009). However, the changes of VAS were positively related to the changes in vessel density of the tarsal conjunctiva (R 2 =0.11, P =0.02). The changes of ocular microvasculature were not related to the objective metrics of the lens-fitting characteristics ( P >0.05). Similarly, the changes in the VAS comfort score were not related to the objective metrics of the lens-fitting characteristics ( P >0.05). CONCLUSION: Contact lens discomfort seemed to relate to lid wiper microvascular responses rather than fitting characteristics after 1 day of contact lens adaptation by neophytes.
PURPOSE: To determine associations between lid wiper microvascular responses, lens fit, and comfort after 1 day of contact lens adaptation by neophytes. METHODS: Functional slitlamp biomicroscopy was used to image the microvascular network of the upper tarsal conjunctiva, lid wiper, and bulbar conjunctiva. Fractal dimension was obtained to represent vessel density. Ultra-high-resolution optical coherence tomography was used to image the lens edge and fitting characteristics, including lens movement and lens-induced conjunctival indentation. Ocular comfort was rated using a 50-point visual analogue scale (VAS). Forty-nine healthy subjects without a history of contact lens wear were recruited. A contact lens was then fitted in the right eye. Imaging was taken at baseline and 6 hr after lens wear. RESULTS: The changes of VAS comfort score were negatively related to the changes of the vessel density in the lid-wiper (R 2 =0.18, P =0.002) and bulbar conjunctiva (R 2 =0.13, P =0.009). However, the changes of VAS were positively related to the changes in vessel density of the tarsal conjunctiva (R 2 =0.11, P =0.02). The changes of ocular microvasculature were not related to the objective metrics of the lens-fitting characteristics ( P >0.05). Similarly, the changes in the VAS comfort score were not related to the objective metrics of the lens-fitting characteristics ( P >0.05). CONCLUSION: Contact lens discomfort seemed to relate to lid wiper microvascular responses rather than fitting characteristics after 1 day of contact lens adaptation by neophytes.
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