Literature DB >> 35578810

Tau: a phase in the crowd.

Vera I Wiersma1, Ruben Rigort1, Magdalini Polymenidou1.   

Abstract

From the management of microtubules to the production of pathological species: liquid-liquid phase separation may tune the behavior of the protein tau in health and neurodegenerative disease. In this issue of The EMBO Journal, Hochmair et al (2022) demystify important aspects of tau condensate compilation.
© 2022 The Authors.

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Year:  2022        PMID： 35578810      PMCID： PMC9156963          DOI： 10.15252/embj.2022111425

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   14.012


  12 in total

1.  Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients.

Authors:  C Bancher; H Braak; P Fischer; K A Jellinger
Journal:  Neurosci Lett       Date:  1993-11-12       Impact factor: 3.046

Review 2.  How crowded is the cytoplasm?

Authors:  A B Fulton
Journal:  Cell       Date:  1982-09       Impact factor: 41.582

3.  Tau: a phase in the crowd.

Authors:  Vera I Wiersma; Ruben Rigort; Magdalini Polymenidou
Journal:  EMBO J       Date:  2022-05-17       Impact factor: 14.012

4.  Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates.

Authors:  Janine Hochmair; Christian Exner; Maximilian Franck; Alvaro Dominguez-Baquero; Lisa Diez; Hévila Brognaro; Matthew L Kraushar; Thorsten Mielke; Helena Radbruch; Senthilvelrajan Kaniyappan; Sven Falke; Eckhard Mandelkow; Christian Betzel; Susanne Wegmann
Journal:  EMBO J       Date:  2022-03-17       Impact factor: 14.012

Review 5.  Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force.

Authors:  Aurélie Zbinden; Manuela Pérez-Berlanga; Pierre De Rossi; Magdalini Polymenidou
Journal:  Dev Cell       Date:  2020-10-12       Impact factor: 12.270

Review 6.  The Hitchhiker's Guide to Nucleocytoplasmic Trafficking in Neurodegeneration.

Authors:  Stephen Moore; Benjamin E Rabichow; Rita Sattler
Journal:  Neurochem Res       Date:  2020-02-21       Impact factor: 3.996

7.  Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.

Authors:  Amayra Hernández-Vega; Marcus Braun; Lara Scharrel; Marcus Jahnel; Susanne Wegmann; Bradley T Hyman; Simon Alberti; Stefan Diez; Anthony A Hyman
Journal:  Cell Rep       Date:  2017-09-05       Impact factor: 9.423

8.  RNA stores tau reversibly in complex coacervates.

Authors:  Xuemei Zhang; Yanxian Lin; Neil A Eschmann; Hongjun Zhou; Jennifer N Rauch; Israel Hernandez; Elmer Guzman; Kenneth S Kosik; Songi Han
Journal:  PLoS Biol       Date:  2017-07-06       Impact factor: 8.029

9.  Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.

Authors:  Nora Bengoa-Vergniory; Elisavet Velentza-Almpani; Ana Maria Silva; Connor Scott; Mariana Vargas-Caballero; Magdalena Sastre; Richard Wade-Martins; Javier Alegre-Abarrategui
Journal:  Acta Neuropathol Commun       Date:  2021-01-28       Impact factor: 7.801

10.  Tau protein liquid-liquid phase separation can initiate tau aggregation.

Authors:  Susanne Wegmann; Bahareh Eftekharzadeh; Katharina Tepper; Katarzyna M Zoltowska; Rachel E Bennett; Simon Dujardin; Pawel R Laskowski; Danny MacKenzie; Tarun Kamath; Caitlin Commins; Charles Vanderburg; Allyson D Roe; Zhanyun Fan; Amandine M Molliex; Amayra Hernandez-Vega; Daniel Muller; Anthony A Hyman; Eckhard Mandelkow; J Paul Taylor; Bradley T Hyman
Journal:  EMBO J       Date:  2018-02-22       Impact factor: 11.598
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  2 in total

1.  Tau: a phase in the crowd.

Authors:  Vera I Wiersma; Ruben Rigort; Magdalini Polymenidou
Journal:  EMBO J       Date:  2022-05-17       Impact factor: 14.012

Review 2.  Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis.

Authors:  Ilaria Tortorella; Chiara Argentati; Carla Emiliani; Francesco Morena; Sabata Martino
Journal:  Cells       Date:  2022-10-01       Impact factor: 7.666
  2 in total

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