HDL and microRNAs.

In previous chapters, we know that high-density lipoproteins (HDLs) could act at multiple cell lines and then trigger intracellular molecular pathway to prevent several metabolic diseases. Besides the classic genes regulating cholesterol efflux and reverse cholesterol transport (RCT), microRNAs (miRNAs) could also affect HDLs biogenesis, metabolism, and functions. This chapter summarizes the miRNAs, which regulate HDLs functions in table. In addition, HDLs are good vectors for miRNAs. They could carry miRNAs in circulation and take them into several cells such as macrophages and endothelial cells. Complete understanding of the miRNAs associated with HDL regulation would give us broader insights to prevent and treat metabolic diseases.