Iris M Hagemans1,2, Peter J Wierstra3, Sandra Heskamp4, Martijn Verdoes5,6, Kas Steuten1,2, Janneke D M Molkenboer-Kuenen3, Duco van Dalen1,2, Martin Ter Beest1, Johan M S van der Schoot1, Olga Ilina1,2, Martin Gotthardt3, Carl G Figdor1,2,7, Ferenc A Scheeren8. 1. Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. 2. Institute for Chemical Immunology, Nijmegen, The Netherlands. 3. Department of Medical Imaging, Nuclear Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. 4. Department of Medical Imaging, Nuclear Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Sandra.Heskamp@Radboudumc.nl. 5. Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Martijn.Verdoes@Radboudumc.nl. 6. Institute for Chemical Immunology, Nijmegen, The Netherlands. Martijn.Verdoes@Radboudumc.nl. 7. Division of Immunotherapy, Oncode Institute, Radboud University Medical Center, Nijmegen, The Netherlands. 8. Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.
Correction to: Journal of Nanobiotechnology (2022) 20:64 https://doi.org/10.1186/s12951-022-01272-5
Following publication of the original article [1], the authors identified an error in Fig. 1 and Fig. 4. The correct figures are given in this correction article.The error was in the “R-groups” (R1 and R2) of the molecules IH18 and IH20 in Fig. 1b and in Additional file 1: Figure S1. R1 and R2 were accidently swapped. In Fig. 4d the error was in the depiction of the tumor/blood ratio. During transfer of the data to this bar graph the data got unintentionally transformed.
Fig. 1
Molecular toolbox of site-specific functionalizable anti-PD-L1 antibody formats and imaging peptides. A Application of the CRISPR/HDR strategy to anti-PD-L1 hybridoma MIH5 created a sortaggable Fab fragment and chimeric mouse IgG1 monoclonal antibody against PD-L1. B Molecular structure of imaging peptides IH20 and IH18
Fig. 4
Biodistribution results of anti-PD-L1 multimodal imaging tools. Biodistribution is shown at several time points after injection (p.i.) of 111In-labeled A mIgG1-IH18, B Fab-IH18 or C Fab-IH18-PEG. D Tumor uptake values (left graph) and tumor/blood ratios (right graph) of the three constructs are compared directly at each time point. Data are shown as mean ± SD, n = 5
Molecular toolbox of site-specific functionalizable anti-PD-L1 antibody formats and imaging peptides. A Application of the CRISPR/HDR strategy to anti-PD-L1 hybridoma MIH5 created a sortaggable Fab fragment and chimeric mouse IgG1 monoclonal antibody against PD-L1. B Molecular structure of imaging peptides IH20 and IH18Biodistribution results of anti-PD-L1 multimodal imaging tools. Biodistribution is shown at several time points after injection (p.i.) of 111In-labeled A mIgG1-IH18, B Fab-IH18 or C Fab-IH18-PEG. D Tumor uptake values (left graph) and tumor/blood ratios (right graph) of the three constructs are compared directly at each time point. Data are shown as mean ± SD, n = 5Additional file 1. Supplementary figures and tables.
Authors: Iris M Hagemans; Peter J Wierstra; Sandra Heskamp; Martijn Verdoes; Kas Steuten; Janneke D M Molkenboer-Kuenen; Duco van Dalen; Martin Ter Beest; Johan M S van der Schoot; Olga Ilina; Martin Gotthardt; Carl G Figdor; Ferenc A Scheeren Journal: J Nanobiotechnology Date: 2022-02-02 Impact factor: 10.435