Literature DB >> 35568872

Correction to: Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents Iris.

Iris M Hagemans1,2, Peter J Wierstra3, Sandra Heskamp4, Martijn Verdoes5,6, Kas Steuten1,2, Janneke D M Molkenboer-Kuenen3, Duco van Dalen1,2, Martin Ter Beest1, Johan M S van der Schoot1, Olga Ilina1,2, Martin Gotthardt3, Carl G Figdor1,2,7, Ferenc A Scheeren8.   

Abstract

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Year:  2022        PMID: 35568872      PMCID: PMC9107661          DOI: 10.1186/s12951-022-01306-y

Source DB:  PubMed          Journal:  J Nanobiotechnology        ISSN: 1477-3155            Impact factor:   9.429


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Correction to: Journal of Nanobiotechnology (2022) 20:64 https://doi.org/10.1186/s12951-022-01272-5

Following publication of the original article [1], the authors identified an error in Fig. 1 and Fig. 4. The correct figures are given in this correction article. The error was in the “R-groups” (R1 and R2) of the molecules IH18 and IH20 in Fig. 1b and in Additional file 1: Figure S1. R1 and R2 were accidently swapped. In Fig. 4d the error was in the depiction of the tumor/blood ratio. During transfer of the data to this bar graph the data got unintentionally transformed.
Fig. 1

Molecular toolbox of site-specific functionalizable anti-PD-L1 antibody formats and imaging peptides. A Application of the CRISPR/HDR strategy to anti-PD-L1 hybridoma MIH5 created a sortaggable Fab fragment and chimeric mouse IgG1 monoclonal antibody against PD-L1. B Molecular structure of imaging peptides IH20 and IH18

Fig. 4

Biodistribution results of anti-PD-L1 multimodal imaging tools. Biodistribution is shown at several time points after injection (p.i.) of 111In-labeled A mIgG1-IH18, B Fab-IH18 or C Fab-IH18-PEG. D Tumor uptake values (left graph) and tumor/blood ratios (right graph) of the three constructs are compared directly at each time point. Data are shown as mean ± SD, n = 5

Molecular toolbox of site-specific functionalizable anti-PD-L1 antibody formats and imaging peptides. A Application of the CRISPR/HDR strategy to anti-PD-L1 hybridoma MIH5 created a sortaggable Fab fragment and chimeric mouse IgG1 monoclonal antibody against PD-L1. B Molecular structure of imaging peptides IH20 and IH18 Biodistribution results of anti-PD-L1 multimodal imaging tools. Biodistribution is shown at several time points after injection (p.i.) of 111In-labeled A mIgG1-IH18, B Fab-IH18 or C Fab-IH18-PEG. D Tumor uptake values (left graph) and tumor/blood ratios (right graph) of the three constructs are compared directly at each time point. Data are shown as mean ± SD, n = 5 Additional file 1. Supplementary figures and tables.
  1 in total

1.  Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents.

Authors:  Iris M Hagemans; Peter J Wierstra; Sandra Heskamp; Martijn Verdoes; Kas Steuten; Janneke D M Molkenboer-Kuenen; Duco van Dalen; Martin Ter Beest; Johan M S van der Schoot; Olga Ilina; Martin Gotthardt; Carl G Figdor; Ferenc A Scheeren
Journal:  J Nanobiotechnology       Date:  2022-02-02       Impact factor: 10.435

  1 in total

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