| Literature DB >> 35568751 |
Lun Gao1,2, Zhang Ye1,2, Jun-Hui Liu1,2, Ji-An Yang1,2, Yong Li1,2, Jia-Yang Cai1,2, Yi-Xuan Wang1,2, Shi-Ao Tong1,2, Gang Deng1,2, Shenqi Zhang3,4, Qian-Xue Chen5,6.
Abstract
Transmembrane and coiled-coil domains 1 (TMCO1) is a recently discovered transmembrane protein of endoplasmic reticulum (ER), which plays a critical role in maintaining calcium homeostasis. TMCO1 dysfunction has been proved to be closely related to a variety of human diseases, including glaucoma, deformities, mental retardation and tumorigenesis. However, the role of TMCO1 in gliomas remains unclear. The purpose of this study was to detect the role of TMCO1 in the pathogenesis and progression of gliomas. This study demonstrated that TMCO1 was upregulated in gliomas and its overexpression predicted poor prognosis. We also revealed that the expression of TMCO1 was associated with the World Health Organization (WHO) grade of gliomas. Knockdown of TMCO1 inhibited the proliferation and induced apoptosis of U87 and U251 cells. In addition, TMCO1 induced GBM cell migration and invasion by promoting epithelial-mesenchymal transition (EMT). These date collectively proved the crucial role of TMCO1 as a novel prognostic factor and underlying therapeutic target for glioma patients.Entities:
Keywords: Apoptosis; EMT; Prognosis; Proliferation; TMCO1
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Year: 2022 PMID： 35568751 DOI： 10.1007/s12032-022-01687-y
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064