Literature DB >> 3556585

ATP release from pure cholinergic synaptosomes is not blocked by tetanus toxin.

X Rabasseda, C Solsona, J Marsal, G Egea, B Bizzini.   

Abstract

Tetanus toxin (TeTx) is a neurotransmission impairing toxin that acts on several neurotransmitter systems. TeTx also inhibits the K+-induced release of acetylcholine (ACh) from synaptosomes isolated from the electric organ of Torpedo. Neither the membrane potential and depolarization, nor the depolarization-induced calcium uptake into cholinergic nerve terminals is modified after TeTx poisoning. On the other hand, it is known that, when cholinergic nerve terminals are stimulated, there is a release of ATP associated with the release of ACh. We have explored the action of TeTx on this co-release, and have found that there is no action of TeTx on the nucleotide release. Thus, TeTx blocks ACh release without modifying ATP release.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3556585     DOI： 10.1016/0014-5793(87)81518-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Vesicular release of ATP at central synapses.

Authors:  Yuri Pankratov; Ulyana Lalo; Alexei Verkhratsky; R Alan North
Journal:  Pflugers Arch       Date:  2006-04-26       Impact factor: 3.657

2.  Quantitative analysis of depolarization-induced ATP release from mouse brain synaptosomes: external calcium dependent and independent processes.

Authors:  J L Fiedler; H B Pollard; E Rojas
Journal:  J Membr Biol       Date:  1992-04       Impact factor: 1.843

3.  Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females.

Authors:  Naoto Fujii; Lyra Halili; Maya Sarah Singh; Robert D Meade; Glen P Kenny
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-08-19       Impact factor: 3.619

4.  Intradermal administration of ATP does not mitigate tyramine-stimulated vasoconstriction in human skin.

Authors:  Jonathan E Wingo; R Matthew Brothers; Juan Del Coso; Craig G Crandall
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-03-17       Impact factor: 3.619

5.  Acetylcholine and ATP are coreleased from the electromotor nerve terminals of Narcine brasiliensis by an exocytotic mechanism.

Authors:  C D Unsworth; R G Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

6.  Cutaneous vascular and sweating responses to intradermal administration of ATP: a role for nitric oxide synthase and cyclooxygenase?

Authors:  Naoto Fujii; Ryan McGinn; Lyra Halili; Maya Sarah Singh; Narihiko Kondo; Glen P Kenny
Journal:  J Physiol       Date:  2015-04-17       Impact factor: 5.182

7.  Ectopic vesicular neurotransmitter release along sensory axons mediates neurovascular coupling via glial calcium signaling.

Authors:  Anne Thyssen; Daniela Hirnet; Hartwig Wolburg; Günther Schmalzing; Joachim W Deitmer; Christian Lohr
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-09       Impact factor: 11.205

8.  The field-stimulated vas deferens of the streptozotocin-diabetic mouse: effects of prazosin, alpha, beta-methylene ATP, and variation of stimulation parameters.

Authors:  M Kaschube; H Möller-Hartmann; G Zetler
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

9.  Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression.

Authors:  Smitha Sreedharan; Jafar H A Shaik; Pawel K Olszewski; Allen S Levine; Helgi B Schiöth; Robert Fredriksson
Journal:  BMC Genomics       Date:  2010-01-08       Impact factor: 3.969
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.