MOTIVATION: The evaluation of chemicals for their carcinogenic hazard requires the analysis of a wide range of data and the characterization of these results relative to the key characteristics of carcinogens. The workflow used historically requires many manual steps that are labor-intensive and can introduce errors, bias and inconsistencies. RESULTS: The automation of parts of the evaluation workflow using the kc-hits software has led to significant improvements in process efficiency, as well as more consistent and comprehensive results. AVAILABILITY AND IMPLEMENTATION: https://gitlab.com/i1650/kc-hits.git. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
MOTIVATION: The evaluation of chemicals for their carcinogenic hazard requires the analysis of a wide range of data and the characterization of these results relative to the key characteristics of carcinogens. The workflow used historically requires many manual steps that are labor-intensive and can introduce errors, bias and inconsistencies. RESULTS: The automation of parts of the evaluation workflow using the kc-hits software has led to significant improvements in process efficiency, as well as more consistent and comprehensive results. AVAILABILITY AND IMPLEMENTATION: https://gitlab.com/i1650/kc-hits.git. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Authors: Ann M Richard; Richard S Judson; Keith A Houck; Christopher M Grulke; Patra Volarath; Inthirany Thillainadarajah; Chihae Yang; James Rathman; Matthew T Martin; John F Wambaugh; Thomas B Knudsen; Jayaram Kancherla; Kamel Mansouri; Grace Patlewicz; Antony J Williams; Stephen B Little; Kevin M Crofton; Russell S Thomas Journal: Chem Res Toxicol Date: 2016-07-20 Impact factor: 3.739
Authors: Antony J Williams; Christopher M Grulke; Jeff Edwards; Andrew D McEachran; Kamel Mansouri; Nancy C Baker; Grace Patlewicz; Imran Shah; John F Wambaugh; Richard S Judson; Ann M Richard Journal: J Cheminform Date: 2017-11-28 Impact factor: 5.514
Authors: Martyn T Smith; Kathryn Z Guyton; Catherine F Gibbons; Jason M Fritz; Christopher J Portier; Ivan Rusyn; David M DeMarini; Jane C Caldwell; Robert J Kavlock; Paul F Lambert; Stephen S Hecht; John R Bucher; Bernard W Stewart; Robert A Baan; Vincent J Cogliano; Kurt Straif Journal: Environ Health Perspect Date: 2015-11-24 Impact factor: 9.031
Authors: Jonathan M Samet; Weihsueh A Chiu; Vincent Cogliano; Jennifer Jinot; David Kriebel; Ruth M Lunn; Frederick A Beland; Lisa Bero; Patience Browne; Lin Fritschi; Jun Kanno; Dirk W Lachenmeier; Qing Lan; Gérard Lasfargues; Frank Le Curieux; Susan Peters; Pamela Shubat; Hideko Sone; Mary C White; Jon Williamson; Marianna Yakubovskaya; Jack Siemiatycki; Paul A White; Kathryn Z Guyton; Mary K Schubauer-Berigan; Amy L Hall; Yann Grosse; Véronique Bouvard; Lamia Benbrahim-Tallaa; Fatiha El Ghissassi; Béatrice Lauby-Secretan; Bruce Armstrong; Rodolfo Saracci; Jiri Zavadil; Kurt Straif; Christopher P Wild Journal: J Natl Cancer Inst Date: 2020-01-01 Impact factor: 13.506