Wenyong Zhou1, Kongjun Qiu2. 1. Department of General Surgery, Cangzhou Central Hospital Cangzhou 061001, Hebei, China. 2. Operating Room, Cangzhou People's Hospital Cangzhou 061000, Hebei, China.
Abstract
OBJECTIVES: To explore and analyze the correlation between lncRNA NEAT1 and serum hepcidin (HEPC) in the peripheral blood of non-alcoholic fatty liver disease patients. METHODS: 119 patients, confirmed to have non-alcoholic fatty liver disease (NAFLD) and admitted to our hospital from January 2017 to June 2019, were enrolled in the NAFLD group, and 100 healthy subjects during the same period were enrolled in the control group. We recorded the two groups' general information and routine laboratory examination results and performed correlation analyses on the lncRNA NEAT1 expressions in their peripheral blood mononuclear cells (PBMCs) and HEPC. RESULTS: The BMI, the waist circumferences, and the ALT, GGT, TC, and TG levels in the NAFLD group were critically higher than they were in the control group (P<0.05). The relative expressions of lncRNA NEAT1 in the PBMCs of the NAFLD group were remarkably higher than they were in the control group (P<0.05). The HEPC levels in the NAFLD group were significantly higher than they were in the control group (P<0.05). The lncRNA NEAT1 expressions in the NAFLD patients presented a remarkable positive correlation with the ALT, GGT, TC, and TG levels (P<0.05). The HEPC levels were positively correlated with the ALT, GGT, TC, and TG levels in the NAFLD patients (P<0.05), and the lncRNA NEAT1 expressions in the peripheral blood had a positive correlation with HEPC (P<0.05). We used ROC curves to analyze the diagnostic value of lncRNA NEAT1 in the peripheral blood to NAFLD, and the area under the curve was 0.822 (95% confidence interval of overall probability: 0.612~0.921). The sensitivity was 86.47%, and the specificity was 82.03%. CONCLUSION: lncRNA NEAT1 is abnormally overexpressed in the PBMCs of patients with NAFLD. The regulatory effect of lncRNA NEAT1 on NAFLD may be related to the mechanism of HEPC, which is expected to be a potential biological indicator for the prevention and treatment of NAFLD. AJTR
OBJECTIVES: To explore and analyze the correlation between lncRNA NEAT1 and serum hepcidin (HEPC) in the peripheral blood of non-alcoholic fatty liver disease patients. METHODS: 119 patients, confirmed to have non-alcoholic fatty liver disease (NAFLD) and admitted to our hospital from January 2017 to June 2019, were enrolled in the NAFLD group, and 100 healthy subjects during the same period were enrolled in the control group. We recorded the two groups' general information and routine laboratory examination results and performed correlation analyses on the lncRNA NEAT1 expressions in their peripheral blood mononuclear cells (PBMCs) and HEPC. RESULTS: The BMI, the waist circumferences, and the ALT, GGT, TC, and TG levels in the NAFLD group were critically higher than they were in the control group (P<0.05). The relative expressions of lncRNA NEAT1 in the PBMCs of the NAFLD group were remarkably higher than they were in the control group (P<0.05). The HEPC levels in the NAFLD group were significantly higher than they were in the control group (P<0.05). The lncRNA NEAT1 expressions in the NAFLD patients presented a remarkable positive correlation with the ALT, GGT, TC, and TG levels (P<0.05). The HEPC levels were positively correlated with the ALT, GGT, TC, and TG levels in the NAFLD patients (P<0.05), and the lncRNA NEAT1 expressions in the peripheral blood had a positive correlation with HEPC (P<0.05). We used ROC curves to analyze the diagnostic value of lncRNA NEAT1 in the peripheral blood to NAFLD, and the area under the curve was 0.822 (95% confidence interval of overall probability: 0.612~0.921). The sensitivity was 86.47%, and the specificity was 82.03%. CONCLUSION: lncRNA NEAT1 is abnormally overexpressed in the PBMCs of patients with NAFLD. The regulatory effect of lncRNA NEAT1 on NAFLD may be related to the mechanism of HEPC, which is expected to be a potential biological indicator for the prevention and treatment of NAFLD. AJTR
Authors: Carlos J Pirola; Tomas Fernández Gianotti; Gustavo O Castaño; Pablo Mallardi; Julio San Martino; María Mora Gonzalez Lopez Ledesma; Diego Flichman; Faridodin Mirshahi; Arun J Sanyal; Silvia Sookoian Journal: Gut Date: 2014-06-27 Impact factor: 23.059
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