Literature DB >> 3555580

A quinine a day keeps the leg cramps away?

A Warburton, J P Royston, C J O'Neill, P W Nicholson, R D Jee, M J Denham, S M Dobbs, R J Dobbs.   

Abstract

A double-blind, placebo-controlled, cross-over trial of quinine in leg cramps occurring at rest was conducted in 22 elderly cramp sufferers. Despite demonstration of impaired quinine elimination in the elderly, prescription of the traditional dose of 300 mg quinine bisulphate at night failed to produce a significant (P = 0.1) reduction in the number or severity of cramps. There was a significant relationship between serum quinine concentration and attenuation of cramps. However, the simple expedient of increasing the nightly dose of quinine may carry the concomitant risk of cinchonism.

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Year:  1987        PMID： 3555580      PMCID： PMC1386096          DOI： 10.1111/j.1365-2125.1987.tb03076.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  7 in total

1.  QUANTITATIVE DETERMINATION OF QUINIDINE IN PLASMA.

Authors:  G CRAMER; B ISAKSSON
Journal:  Scand J Clin Lab Invest       Date:  1963       Impact factor: 1.713

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Authors:  D E Drayer; K Restivo; M M Reidenberg
Journal:  J Lab Clin Med       Date:  1977-11

3.  The two-period cross-over clinical trial.

Authors:  M Hills; P Armitage
Journal:  Br J Clin Pharmacol       Date:  1979-07       Impact factor: 4.335

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Authors:  J C Garnham; K Raymond; E Shotton; P Turner
Journal:  J Trop Med Hyg       Date:  1976-12

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Authors:  C M Berlin; J M Stackman; E S Vesell
Journal:  Clin Pharmacol Ther       Date:  1975-12       Impact factor: 6.875

6.  Reduced induction of drug metabolism in the elderly.

Authors:  S A Salem; P Rajjayabun; A M Shepherd; I H Stevenson
Journal:  Age Ageing       Date:  1978-05       Impact factor: 10.668

7.  A double-blind comparison of quinine sulphate and placebo in muscle cramps.

Authors:  K Jones; C M Castleden
Journal:  Age Ageing       Date:  1983-05       Impact factor: 10.668
  7 in total
  13 in total

Review 1.  Nocturnal leg cramps in older people.

Authors:  J V Butler; E C Mulkerrin; S T O'Keeffe
Journal:  Postgrad Med J       Date:  2002-10       Impact factor: 2.401

2.  Effectiveness of quinine for night cramps.

Authors:  N R Dunn
Journal:  Br J Gen Pract       Date:  1993-03       Impact factor: 5.386

Review 3.  Non-drug therapies for lower limb muscle cramps.

Authors:  Fiona Blyton; Vivienne Chuter; Kate E L Walter; Joshua Burns
Journal:  Cochrane Database Syst Rev       Date:  2012-01-18

4.  Placebo-controlled trial of quinine therapy for nocturnal leg cramps.

Authors:  M C Fung; J H Holbrook
Journal:  West J Med       Date:  1989-07

5.  Naftidrofuryl treatment for rest cramp.

Authors:  J B Young; M J Connolly
Journal:  Postgrad Med J       Date:  1993-08       Impact factor: 2.401

6.  Quinine pharmacokinetics in chronic haemodialysis patients.

Authors:  Louise Roy; Pierre Bannon; Jean-Pierre Villeneuve
Journal:  Br J Clin Pharmacol       Date:  2002-12       Impact factor: 4.335

7.  Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people.

Authors:  M Man-Son-Hing; G Wells
Journal:  BMJ       Date:  1995-01-07

8.  The pharmacokinetics and pharmacodynamics of quinine in the diabetic and non-diabetic elderly.

Authors:  J R Dyer; T M Davis; C Giele; T Annus; P Garcia-Webb; J Robson
Journal:  Br J Clin Pharmacol       Date:  1994-09       Impact factor: 4.335

9.  Quinine for nocturnal leg cramps: a meta-analysis including unpublished data.

Authors:  M Man-Son-Hing; G Wells; A Lau
Journal:  J Gen Intern Med       Date:  1998-09       Impact factor: 5.128

10.  Non-drug therapies for the secondary prevention of lower limb muscle cramps.

Authors:  Fiona Hawke; Sean G Sadler; Hans Dieter Katzberg; Fereshteh Pourkazemi; Vivienne Chuter; Joshua Burns
Journal:  Cochrane Database Syst Rev       Date:  2021-05-17
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