| Literature DB >> 35554911 |
Dhiraj K Singh1,2, Journey Cole1,2, Ruby A Escobedo1,2, Kendra J Alfson2, Bindu Singh1,2, Tae-Hyung Lee1,2, Xavier Alvarez1,2, Shashank R Ganatra1,2, Ricardo Carrion2, Deepak Kaushal3,4.
Abstract
With the advent of the novel SARS-CoV-2, the entire world has been thrown into chaos with severe disruptions from a normal life. While the entire world was going chaotic, the researchers throughout the world were struggling to contribute to the best of their capabilities to advance the understanding of this new pandemic and fast track the development of novel therapeutics and vaccines. While various animal models have helped a lot to understand the basic physiology, nonhman primates have been promising and much more successful in modelling human diseases compared to other available clinical models. Here we describe the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in NHP immunology.Entities:
Keywords: Animal models; BAL; COVID-19; Computed tomography; Cone beam; Confocal microscopy; FACS; Flow cytometry; IHC; In vivo imaging; NHP; Nonhuman primates; Rhesus macaques; SARS-CoV-2; X-rays
Mesh：
Year: 2022 PMID： 35554911 DOI： 10.1007/978-1-0716-2111-0_15
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745