Trevin E Glasgow1, Elizabeth L Adams2, Albert Ksinan3, D Jeremy Barsell1, Jessica Lunsford-Avery4, Shanshan Chen5, Scott Kollins6, Julia C Schechter4, Rachel Maguire7,8, Matthew Engelhard9, Bernard F Fuemmeler10. 1. Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA. 2. Department of Exercise Science, University of South Carolina, Columbia, SC, USA. 3. RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic. 4. Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA. 5. Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA. 6. Holmusk, Durham, NC, USA. 7. Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA. 8. Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 9. Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA. 10. Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA. bernard.fuemmeler@vcuhealth.org.
Abstract
BACKGROUND/ OBJECTIVES: Sleep measures, such as duration and onset timing, are associated with adiposity outcomes among children. Recent research among adults has considered variability in sleep and wake onset times, with the Sleep Regularity Index (SRI) as a comprehensive metric to measure shifts in sleep and wake onset times between days. However, little research has examined regularity and adiposity outcomes among children. This study examined the associations of three sleep measures (i.e., sleep duration, sleep onset time, and SRI) with three measures of adiposity (i.e., body mass index [BMI], waist circumference, and waist-to-height ratio [WHtR]) in a pediatric sample. SUBJECTS/ METHODS: Children (ages 4-13 years) who were part of the U.S. Newborn Epigenetic STudy (NEST) participated. Children (N = 144) wore an ActiGraph for 1 week. Sleep measures were estimated from actigraphy data. Weight, height, and waist circumference were measured by trained researchers. BMI and WHtR was calculated with the objectively measured waist and height values. Multiple linear regression models examined associations between child sleep and adiposity outcomes, controlling for race/ethnicity, child sex, age, mothers' BMI and sleep duration. RESULTS: When considering sleep onset timing and duration, along with demographic covariates, sleep onset timing was not significantly associated with any of the three adiposity measures, but a longer duration was significantly associated with a lower BMI Z-score (β = -0.29, p < 0.001), waist circumference (β = -0.31, p < 0.001), and WHtR (β = -0.38, p < 0.001). When considering SRI and duration, duration remained significantly associated with the adiposity measures. The SRI and adiposity associations were in the expected direction, but were non-significant, except the SRI and WHtR association (β = -0.16, p = 0.077) was marginally non-significant. CONCLUSIONS: Sleep duration was consistently associated with adiposity measures in children 4-13 years of age. Pediatric sleep interventions should focus first on elongating nighttime sleep duration, and examine if this improves child adiposity outcomes.
BACKGROUND/ OBJECTIVES: Sleep measures, such as duration and onset timing, are associated with adiposity outcomes among children. Recent research among adults has considered variability in sleep and wake onset times, with the Sleep Regularity Index (SRI) as a comprehensive metric to measure shifts in sleep and wake onset times between days. However, little research has examined regularity and adiposity outcomes among children. This study examined the associations of three sleep measures (i.e., sleep duration, sleep onset time, and SRI) with three measures of adiposity (i.e., body mass index [BMI], waist circumference, and waist-to-height ratio [WHtR]) in a pediatric sample. SUBJECTS/ METHODS: Children (ages 4-13 years) who were part of the U.S. Newborn Epigenetic STudy (NEST) participated. Children (N = 144) wore an ActiGraph for 1 week. Sleep measures were estimated from actigraphy data. Weight, height, and waist circumference were measured by trained researchers. BMI and WHtR was calculated with the objectively measured waist and height values. Multiple linear regression models examined associations between child sleep and adiposity outcomes, controlling for race/ethnicity, child sex, age, mothers' BMI and sleep duration. RESULTS: When considering sleep onset timing and duration, along with demographic covariates, sleep onset timing was not significantly associated with any of the three adiposity measures, but a longer duration was significantly associated with a lower BMI Z-score (β = -0.29, p < 0.001), waist circumference (β = -0.31, p < 0.001), and WHtR (β = -0.38, p < 0.001). When considering SRI and duration, duration remained significantly associated with the adiposity measures. The SRI and adiposity associations were in the expected direction, but were non-significant, except the SRI and WHtR association (β = -0.16, p = 0.077) was marginally non-significant. CONCLUSIONS: Sleep duration was consistently associated with adiposity measures in children 4-13 years of age. Pediatric sleep interventions should focus first on elongating nighttime sleep duration, and examine if this improves child adiposity outcomes.
Authors: Constanza M Vidal Bustamante; Alexandra M Rodman; Meg J Dennison; John C Flournoy; Patrick Mair; Katie A McLaughlin Journal: J Child Psychol Psychiatry Date: 2020-03-17 Impact factor: 8.982
Authors: Ying Liu; Susan K Murphy; Amy P Murtha; Bernard F Fuemmeler; Joellen Schildkraut; Zhiqing Huang; Francine Overcash; Joanne Kurtzberg; Randy Jirtle; Edwin S Iversen; Michele R Forman; Cathrine Hoyo Journal: Epigenetics Date: 2012-07-01 Impact factor: 4.528
Authors: Jessica R Lunsford-Avery; Katherine S F Damme; Matthew M Engelhard; Scott H Kollins; Vijay A Mittal Journal: Sci Rep Date: 2020-01-16 Impact factor: 4.379