Literature DB >> 35549614

Nup50 plays more than one instrument.

Guillaume Holzer1, Wolfram Antonin1.   

Abstract

Nup50 is nuclear pore complex component localized to the nuclear side of the pore and in the nucleoplasm. It has been characterized as an auxiliary factor in nuclear transport reactions. Our recent work indicates that it interacts with and stimulates RCC1, the sole guanine nucleotide exchange factor for the GTPase Ran. Here, we discuss how this interaction might contribute to Nup50 function in nuclear transport but also its other functions like control of gene expression, cell cycle and DNA damage repair.

Entities:  

Keywords:  DNA repair; Nup50; RCC1; cell cycle; nuclear pore assembly; nuclear trafficking; p27Kip1

Mesh：

Substances：

Year:  2022        PMID： 35549614      PMCID： PMC9359400          DOI： 10.1080/15384101.2022.2074742

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   5.173


  61 in total

1.  Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor.

Authors:  Y Zeng; K Hirano; M Hirano; J Nishimura; H Kanaide
Journal:  Biochem Biophys Res Commun       Date:  2000-07-21       Impact factor: 3.575

2.  Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.

Authors:  Victor Bernier-Villamor; Deborah A Sampson; Michael J Matunis; Christopher D Lima
Journal:  Cell       Date:  2002-02-08       Impact factor: 41.582

3.  Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.

Authors:  Peter Askjaer; Vincent Galy; Eva Hannak; Iain W Mattaj
Journal:  Mol Biol Cell       Date:  2002-12       Impact factor: 4.138

4.  Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm.

Authors:  Bernike Kalverda; Helen Pickersgill; Victor V Shloma; Maarten Fornerod
Journal:  Cell       Date:  2010-02-05       Impact factor: 41.582

5.  Structural characterization of altered nucleoporin Nup153 expression in human cells by thin-section electron microscopy.

Authors:  Vincent Duheron; Guillaume Chatel; Ursula Sauder; Vesna Oliveri; Birthe Fahrenkrog
Journal:  Nucleus       Date:  2014       Impact factor: 4.197

6.  Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.

Authors:  Douglas R Mackay; Amanda C Howa; Theresa L Werner; Katharine S Ullman
Journal:  J Cell Sci       Date:  2017-07-27       Impact factor: 5.285

Review 7.  p27Kip1 and human cancers: A reappraisal of a still enigmatic protein.

Authors:  Debora Bencivenga; Ilaria Caldarelli; Emanuela Stampone; Francesco Paolo Mancini; Maria Luisa Balestrieri; Fulvio Della Ragione; Adriana Borriello
Journal:  Cancer Lett       Date:  2017-07-05       Impact factor: 8.679

8.  Nup2p is located on the nuclear side of the nuclear pore complex and coordinates Srp1p/importin-alpha export.

Authors:  J K Hood; J M Casolari; P A Silver
Journal:  J Cell Sci       Date:  2000-04       Impact factor: 5.285

9.  Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.

Authors:  Alessandro Ori; Niccolò Banterle; Murat Iskar; Amparo Andrés-Pons; Claudia Escher; Huy Khanh Bui; Lenore Sparks; Victor Solis-Mezarino; Oliver Rinner; Peer Bork; Edward A Lemke; Martin Beck
Journal:  Mol Syst Biol       Date:  2013       Impact factor: 11.429

10.  Simple rules for passive diffusion through the nuclear pore complex.

Authors:  Benjamin L Timney; Barak Raveh; Roxana Mironska; Jill M Trivedi; Seung Joong Kim; Daniel Russel; Susan R Wente; Andrej Sali; Michael P Rout
Journal:  J Cell Biol       Date:  2016-10-03       Impact factor: 10.539
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