| Literature DB >> 35549570 |
Anand Krishnan1,2, Prakash Gangadaran3,4, Vivek P Chavda5, Manasi P Jogalekar6, Ramesh Muthusamy7, Disha Valu8, Chithravel Vadivalagan9, Prasanna Ramani10,11, Alexey Laishevtcev12,13, Naresh Kumar Katari14, Byeong-Cheol Ahn3,4.
Abstract
The spread of SARS-CoV-2 over the entire world is more commonly known as COVID-19. COVID-19 has impacted society in every aspect of routine life. SARS-CoV-2 infection is often misdiagnosed as influenza or seasonal upper respiratory tract viral infections. General diagnostic tools can detect the viral antigen or isotypes of antibodies. However, inter- and intraindividual variations in antibody levels can cause false negatives in antibody immunoassays. On the contrary, the false-positive test results can also occur due to either cross-reactivity of the viral antigens or some other patient-related autoimmune factors. There is need for a cogent diagnostic tool with more specificity, selectivity, and reliability. Here, we have described the potential of convalescent serum-derived exosome as a diagnostic tool for the detection of SARS-CoV-2, even in asymptomatic patients, which is a limitation for currently practiced diagnostic tests throughout the globe. In addition, its potential as a vehicle for messenger RNA (mRNA) delivery is also emphasized.Entities:
Keywords: COVID-19; Convalescent serum; SARS-CoV-2; diagnostic tool; exosomes; mRNA
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Year: 2022 PMID： 35549570 PMCID： PMC9379609 DOI： 10.1177/15353702221092984
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699