| Literature DB >> 35544733 |
Jianquan Zhu1, Chao Zhang1, Luyi Liu1, Chaoyun Xue1, Yukun Cai1, Xiao-Yu Liu1, Fei Xue1, Yong Qin1.
Abstract
An asymmetric total synthesis of the sarpagine alkaloid (-)-normacusine B is presented. Salient features of this synthesis include a photocatalytic nitrogen-centered radical cascade reaction to assemble the tetrahydrocarbolinone skeleton, a titanium-mediated intramolecular amide-alkene coupling to construct the bridged azabicyclo[3.3.1]nonane moiety, and a nickel-catalyzed reductive Heck coupling to assemble the azabicyclo[2.2.2]octane ring system.Entities:
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Year: 2022 PMID： 35544733 DOI： 10.1021/acs.orglett.2c01177
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005