Literature DB >> 35538238

Bispecific antibodies pin down cancer stem cells.

M Teresa Villanueva.   

Abstract

Entities:  

Keywords:  Biotechnology; Cancer; Drug discovery; Stem cells

Mesh：

Substances：

Year:  2022        PMID： 35538238     DOI： 10.1038/d41573-022-00086-2

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  1 in total

1.  Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.

Authors:  Bram Herpers; Berina Eppink; Mark I James; Carme Cortina; Adrià Cañellas-Socias; Sylvia F Boj; Xavier Hernando-Momblona; Dominik Glodzik; Rob C Roovers; Marc van de Wetering; Carina Bartelink-Clements; Vanessa Zondag-van der Zande; Jara García Mateos; Kuan Yan; Lucia Salinaro; Abdul Basmeleh; Szabolcs Fatrai; David Maussang; Jeroen J Lammerts van Bueren; Irene Chicote; Garazi Serna; Laia Cabellos; Lorena Ramírez; Paolo Nuciforo; Ramon Salazar; Cristina Santos; Alberto Villanueva; Camille Stephan-Otto Attolini; Elena Sancho; Hector G Palmer; Josep Tabernero; Michael R Stratton; John de Kruif; Ton Logtenberg; Hans Clevers; Leo S Price; Robert G J Vries; Eduard Batlle; Mark Throsby
Journal:  Nat Cancer       Date:  2022-04-25
  1 in total

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