| Literature DB >> 3553738 |
T A Niewold, P R Hol, A C van Andel, E T Lutz, E Gruys.
Abstract
An extract (fibril amyloid-enhancing factor) prepared by sonication of a suspension of water-purified hamster AA-amyloid fibrils showed an amyloid-enhancing effect upon intraperitoneal injection into hamsters. The fibril amyloid-enhancing factor was identical to the original fibrils according to the results of infrared spectroscopy, gel filtration, gel electrophoresis, and Western blotting; although lyophilized samples of the extract did not show any green birefringence after staining with Congo red. From these results, it was concluded that fibril amyloid-enhancing factor represents small fragments of amyloid fibrils which enhance in vivo formation of amyloid fibrils.Entities:
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Year: 1987 PMID: 3553738
Source DB: PubMed Journal: Lab Invest ISSN: 0023-6837 Impact factor: 5.662