Yulia Y Orlova1, Sandhya Mehla2, Abigail L Chua3. 1. University of Florida, 1149 Newell Dr., L3-100, Gainesville, 32611, USA. Yulia.Orlova@neurology.ufl.edu. 2. Ayer Neurosciences Institute, Hartford Health Care Medical Group, University of Connecticut School of Medicine, Norwich, CT, USA. 3. Geisinger Health Systems, 1000 E. Mountain Boulevard, Wilkes-Barre, PA, 18702, USA.
Abstract
PURPOSE OF REVIEW: The aim of this review is to aid in choosing safe options when assessing potential risks of acute migraine treatments based on known mechanisms of action and anticipated safety concerns. RECENT FINDINGS: Part 1 highlights safety issues associated with commonly used medications to treat acute migraine attacks. Strategies to mitigate cardiovascular and gastrointestinal risks of nonsteroidal anti-inflammatory drugs, evaluation of cardiovascular risks of triptan and ergot alkaloids, and precautions with use of antiemetics and the novel drugs gepants and ditans are discussed to help practitioners in clinical decision-making. When available, we included recommendations from professional societies and data from pharmacovigilance systems. While guidelines on efficacy are available, one must also consider the possible risks and adverse effects of a drug when creating treatment plans.
PURPOSE OF REVIEW: The aim of this review is to aid in choosing safe options when assessing potential risks of acute migraine treatments based on known mechanisms of action and anticipated safety concerns. RECENT FINDINGS: Part 1 highlights safety issues associated with commonly used medications to treat acute migraine attacks. Strategies to mitigate cardiovascular and gastrointestinal risks of nonsteroidal anti-inflammatory drugs, evaluation of cardiovascular risks of triptan and ergot alkaloids, and precautions with use of antiemetics and the novel drugs gepants and ditans are discussed to help practitioners in clinical decision-making. When available, we included recommendations from professional societies and data from pharmacovigilance systems. While guidelines on efficacy are available, one must also consider the possible risks and adverse effects of a drug when creating treatment plans.
Authors: Elliott M Antman; Joel S Bennett; Alan Daugherty; Curt Furberg; Harold Roberts; Kathryn A Taubert Journal: Circulation Date: 2007-02-26 Impact factor: 29.690
Authors: H C Diener; G Bussone; H de Liano; A Eikermann; R Englert; T Floeter; V Gallai; H Göbel; E Hartung; M D Jimenez; R Lange; G C Manzoni; G Mueller-Schwefe; G Nappi; L Pinessi; J Prat; F M Puca; F Titus; M Voelker Journal: Cephalalgia Date: 2004-11 Impact factor: 6.292