Literature DB >> 3553523

Increased drug sensitivity in Candida albicans cells accumulating 14-methylated sterols.

O Shimokawa, Y Kato, H Nakayama.   

Abstract

Multiple increases in drug sensitivity were observed in Candida albicans cells that were accumulating 14-methylated sterols as a result of a mutation or clotrimazole treatment. The possibility was suggested that a change in membrane permeability caused by the alteration in sterol composition was responsible for the increased susceptibility.

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Year:  1986        PMID: 3553523

Source DB:  PubMed          Journal:  J Med Vet Mycol        ISSN: 0268-1218


  4 in total

1.  Acetate-mediated growth inhibition in sterol 14alpha-demethylation-deficient cells of Candida albicans.

Authors:  O Shimokawa; H Nakayama
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

2.  Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicans.

Authors:  N D Lees; M C Broughton; D Sanglard; M Bard
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

3.  Relationship between MIC and minimum sterol 14{alpha}-demethylation-inhibitory concentration as a factor in evaluating activities of azoles against various fungal species.

Authors:  Osamu Shimokawa; Masakazu Niimi; Ken Kikuchi; Mitsumasa Saito; Hideko Kajiwara; Shin-Ichi Yoshida
Journal:  J Clin Microbiol       Date:  2005-11       Impact factor: 5.948

4.  Increased sensitivity of Candida albicans cells accumulating 14 alpha-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents.

Authors:  O Shimokawa; H Nakayama
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

  4 in total

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