Literature DB >> 3553308

Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics.

W C Maddrey.   

Abstract

Alcoholic patients run an increased risk of developing hepatotoxicity from doses of acetaminophen within or only moderately above the recommended usual therapeutic doses. In this review I examine the scientific evidence and clinical observations that indicate such a heightened susceptibility of the alcoholic to acetaminophen-induced injury.

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Year:  1987        PMID： 3553308     DOI： 10.1097/00004836-198704000-00014

Source DB:  PubMed          Journal:  J Clin Gastroenterol        ISSN： 0192-0790            Impact factor:   3.062


  4 in total

Review 1.  "Second hit" models of alcoholic liver disease.

Authors:  Hidekazu Tsukamoto; Keigo Machida; Alla Dynnyk; Hasmik Mkrtchyan
Journal:  Semin Liver Dis       Date:  2009-04-22       Impact factor: 6.115

2.  Light to moderate drinking and therapeutic doses of acetaminophen: An assessment of risks for renal dysfunction.

Authors:  Harrison Ndetan; Marion W Evans; Ashwani K Singal; Lane J Brunner; Kirk Calhoun; Karan P Singh
Journal:  Prev Med Rep       Date:  2018-10-24

3.  Acetaminophen toxicity: suicidal vs. accidental.

Authors:  Geeta G Gyamlani; Chirag R Parikh
Journal:  Crit Care       Date:  2002-02-21       Impact factor: 9.097

4.  Downregulation of Glutathione-Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen-Induced Liver Injury through IRE1α ER Stress Signaling.

Authors:  Sou Hyun Kim; Hun Ji Choi; Hyeji Seo; Doyoung Kwon; Jaesuk Yun; Young-Suk Jung
Journal:  Antioxidants (Basel)       Date:  2021-12-05
  4 in total

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