Carlos A Rubio1, Michael Vieth2, Corinna Lang-Schwarz3. 1. Department of Pathology, Karolinska Institute, and University Hospital, Stockholm, Sweden. 2. Friedrich-Alexander-University Erlangen-Nuremberg, Bayreuth, Germany. 3. Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
Abstract
AIM: To report the detection of dysplastic crypts in asymmetric branching (DCAB) in biopsies from patients with ulcerative colitis (UC). PATIENTS AND METHODS: One hundred consecutive endoscopic biopsies from patients with UC undergoing surveillance were reviewed. RESULTS: Three biopsy/cases showed DCAB. The frequency of DCAB varied from two in one case, three in another case, and five in the remaining case. CONCLUSION: The final outcome of DCAB is to generate two or more dysplastic asymmetric offspring-crypts. Repeated DCAB offspring formation, together with new DCAB, would boost the pool of dysplastic crypts, resulting in an exponential expansion of the mucosal area occupied by dysplasia in UC. Copyright 2022, International Institute of Anticancer Research.
AIM: To report the detection of dysplastic crypts in asymmetric branching (DCAB) in biopsies from patients with ulcerative colitis (UC). PATIENTS AND METHODS: One hundred consecutive endoscopic biopsies from patients with UC undergoing surveillance were reviewed. RESULTS: Three biopsy/cases showed DCAB. The frequency of DCAB varied from two in one case, three in another case, and five in the remaining case. CONCLUSION: The final outcome of DCAB is to generate two or more dysplastic asymmetric offspring-crypts. Repeated DCAB offspring formation, together with new DCAB, would boost the pool of dysplastic crypts, resulting in an exponential expansion of the mucosal area occupied by dysplasia in UC. Copyright 2022, International Institute of Anticancer Research.
Authors: Ann-Marie Baker; Biancastella Cereser; Samuel Melton; Alexander G Fletcher; Manuel Rodriguez-Justo; Paul J Tadrous; Adam Humphries; George Elia; Stuart A C McDonald; Nicholas A Wright; Benjamin D Simons; Marnix Jansen; Trevor A Graham Journal: Cell Rep Date: 2014-08-07 Impact factor: 9.423
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