Literature DB >> 3552731

Mode of disulfide bond formation of a heat-stable enterotoxin (STh) produced by a human strain of enterotoxigenic Escherichia coli.

Y Shimonishi, Y Hidaka, M Koizumi, M Hane, S Aimoto, T Takeda, T Miwatani, Y Takeda.   

Abstract

To determine the modes of three disulfide linkages in the heat-stable enterotoxin (STh) produced by a human strain of enterotoxigenic Escherichia coli, we synthesized STh(6-18), which consists of 13 amino acid residues and has the same intramolecular disulfide linkages as native STh [(1985) FEBS Lett. 181, 138-142], by stepwise and selective formation of disulfide bonds using different types of removable protecting groups for the Cys residues. Synthesis of the peptide with different modes of disulfide bond formation provided three peptides consistent with standard STh(6-18) in their physicochemical and biological properties, thereby indicating that the disulfide bonds in STh(6-18) are Cys-Cys-Glu-Leu-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3552731     DOI： 10.1016/0014-5793(87)80134-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  20 in total

1.  Synthesis of Escherichia coli heat-stable enterotoxin STp as a pre-pro form and role of the pro sequence in secretion.

Authors:  K Okamoto; M Takahara
Journal:  J Bacteriol       Date:  1990-09       Impact factor: 3.490

2.  Rectification of two Escherichia coli heat-stable enterotoxin allele sequences and lack of biological effect of changing the carboxy-terminal tyrosine to histidine.

Authors:  L M Guzman-Verduzco; Y M Kupersztoch
Journal:  Infect Immun       Date:  1989-02       Impact factor: 3.441

3.  Importance of disulfide bridges in the structure and activity of Escherichia coli enterotoxin ST1b.

Authors:  J Gariépy; A K Judd; G K Schoolnik
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

4.  Epitope mapping and characterization of antigenic determinants of heat-stable enterotoxin (STh) of enterotoxigenic Escherichia coli by using monoclonal antibodies.

Authors:  T Takeda; G B Nair; K Suzuki; H X Zhe; Y Yokoo; P De Mol; W Hemelhof; J P Butzler; Y Takeda; Y Shimonishi
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

5.  A modular approach to assembly of totally synthetic self-adjuvanting lipopeptide-based vaccines allows conformational epitope building.

Authors:  Weiguang Zeng; Kylie J Horrocks; Gorjana Robevska; Chinn Yi Wong; Kristy Azzopardi; Marija Tauschek; Roy M Robins-Browne; David C Jackson
Journal:  J Biol Chem       Date:  2011-02-14       Impact factor: 5.157

6.  Maturation pathway of Escherichia coli heat-stable enterotoxin I: requirement of DsbA for disulfide bond formation.

Authors:  H Yamanaka; M Kameyama; T Baba; Y Fujii; K Okamoto
Journal:  J Bacteriol       Date:  1994-05       Impact factor: 3.490

7.  Contribution of individual disulfide bonds to biological action of Escherichia coli heat-stable enterotoxin B.

Authors:  Y L Arriaga; B A Harville; L A Dreyfus
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

8.  Receptor guanylyl cyclase C (GC-C): regulation and signal transduction.

Authors:  Nirmalya Basu; Najla Arshad; Sandhya S Visweswariah
Journal:  Mol Cell Biochem       Date:  2009-12-04       Impact factor: 3.396

9.  The Escherichia coli heat-stable enterotoxin is a long-lived superagonist of guanylin.

Authors:  B W Carpick; J Gariépy
Journal:  Infect Immun       Date:  1993-11       Impact factor: 3.441

10.  Substitutions of cysteine residues of Escherichia coli heat-stable enterotoxin by oligonucleotide-directed mutagenesis.

Authors:  K Okamoto; K Okamoto; J Yukitake; Y Kawamoto; A Miyama
Journal:  Infect Immun       Date:  1987-09       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.