| Literature DB >> 35524496 |
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Abstract
Entities:
Year: 2022 PMID: 35524496 PMCID: PMC9077301 DOI: 10.1111/jcmm.17207
Source DB: PubMed Journal: J Cell Mol Med ISSN: 1582-1838 Impact factor: 5.310
FIGURE 3Knockdown of Med19 inhibited BCa cell migration in vitro. (A) wound‐healing assay showed that shMed19‐treated cells migrated significantly slower than the control groups. (B) transwell migration assay, the upper panel showed the migrated cells and the lower panel showed cell numbers. The average migrated cell numbers of shMed19 treatment were significantly decreased compared with controls. *p < 0.05, **p < 0.01
FIGURE 5Inhibition of BCa cell proliferation and migration by Med19 knockdown can be rescued by LiCl. (A) BCa cells were treated with or without 10 mM LiCl, the protein expression of b‐catenin was examined by Western blot. (B) Both MMP‐9 and Cyclin‐D1 protein levels were increased in shMed19 cells treated with LiCl. (C) Cell proliferation assay evaluated the effect of LiCl in BCa cells of shMed19 treatment. (D) Transwell migration assay evaluated the effect of LiCl in BCa cells of shMed19 treatment. b‐actin was used as internal control. *p < 0.05, **p < 0.01