Literature DB >> 35522189

A Kv2 inhibitor traps itself in place.

Ben Short.   

Abstract

Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.
© 2022 Rockefeller University Press.

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Year:  2022        PMID： 35522189      PMCID： PMC9086499          DOI： 10.1085/jgp.202213181

Source DB:  PubMed          Journal:  J Gen Physiol        ISSN： 0022-1295            Impact factor:   4.000


  5 in total

1.  Identification of novel and selective Kv2 channel inhibitors.

Authors:  James Herrington; Kelli Solly; Kevin S Ratliff; Nina Li; Yun-Ping Zhou; Andrew Howard; Laszlo Kiss; Maria L Garcia; Owen B McManus; Qiaolin Deng; Ranjit Desai; Yusheng Xiong; Gregory J Kaczorowski
Journal:  Mol Pharmacol       Date:  2011-09-26       Impact factor: 4.436

2.  Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.

Authors:  David A Jacobson; Andrey Kuznetsov; James P Lopez; Shera Kash; Carina E Ammälä; Louis H Philipson
Journal:  Cell Metab       Date:  2007-09       Impact factor: 27.287

3.  Kv2 channel regulation of action potential repolarization and firing patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons.

Authors:  Pin W Liu; Bruce P Bean
Journal:  J Neurosci       Date:  2014-04-02       Impact factor: 6.167

4.  Mechanism of use-dependent Kv2 channel inhibition by RY785.

Authors:  Matthew James Marquis; Jon T Sack
Journal:  J Gen Physiol       Date:  2022-04-18       Impact factor: 4.000

5.  Status of the intracellular gate in the activated-not-open state of shaker K+ channels.

Authors:  Donato del Camino; Max Kanevsky; Gary Yellen
Journal:  J Gen Physiol       Date:  2005-11       Impact factor: 4.086
  5 in total

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