Literature DB >> 3551953

GnRH-associated peptide (GAP) is cosecreted with GnRH into the hypophyseal portal blood of ovariectomized sheep.

I J Clarke, J T Cummins, F J Karsch, P H Seeburg, K Nikolics.   

Abstract

The secretion of gonadotropin-releasing hormone (GnRH) and GnRH-associated peptide (GAP) into sheep hypothalamo-hypophyseal portal blood was investigated in ovariectomized ewes. GAP and GnRH were cosecreted into portal blood as determined in pooled 'peak' and 'trough' samples. The temporal pattern of GAP secretion into portal blood was coincidental with that of luteinizing hormone (LH) secretion into peripheral blood in three individual animals. The data provide the first evidence that GAP is a secretory product from mammalian hypothalamus and establish the temporal coexistence of the two peptides which appears to be of physiological significance in the regulation of pituitary function.

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Year:  1987        PMID： 3551953     DOI： 10.1016/0006-291x(87)91405-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Hyperpolarization-activated currents in gonadotropin-releasing hormone (GnRH) neurons contribute to intrinsic excitability and are regulated by gonadal steroid feedback.

Authors:  Zhiguo Chu; Hiroshi Takagi; Suzanne M Moenter
Journal:  J Neurosci       Date:  2010-10-06       Impact factor: 6.167

2.  Immunocytochemical localization of the gonadotropin-releasing hormone-associated peptide portion of the LHRH precursor in the hypothalamus and extrahypothalamic regions of the rat central nervous system.

Authors:  I Merchenthaler; M D Culler; P Petrusz; B Flerkó; A Negro-Vilar
Journal:  Cell Tissue Res       Date:  1989-01       Impact factor: 5.249

3.  Immunocytochemical demonstration of GAP-like immunoreactive neuronal elements in the human hypothalamus and pituitary.

Authors:  J Abe; H Okamura; Y Ibata; A Motoyama; I Wakabayashi; N Ling; W K Paull
Journal:  Histochemistry       Date:  1990

Review 4.  Molecular biology of the regulation of hypothalamic hormones.

Authors:  J M Rondeel; I M Jackson
Journal:  J Endocrinol Invest       Date:  1993-03       Impact factor: 4.256

Review 5.  Control of luteinizing hormone-releasing hormone pulse generation in nonhuman primates.

Authors:  E Terasawa
Journal:  Cell Mol Neurobiol       Date:  1995-02       Impact factor: 5.046

Review 6.  Expression and Role of Gonadotropin-Releasing Hormone 2 and Its Receptor in Mammals.

Authors:  Amy T Desaulniers; Rebecca A Cederberg; Clay A Lents; Brett R White
Journal:  Front Endocrinol (Lausanne)       Date:  2017-12-11       Impact factor: 5.555

7.  Conservation of Three-Dimensional Helix-Loop-Helix Structure through the Vertebrate Lineage Reopens the Cold Case of Gonadotropin-Releasing Hormone-Associated Peptide.

Authors:  Daniela I Pérez Sirkin; Anne-Gaëlle Lafont; Nédia Kamech; Gustavo M Somoza; Paula G Vissio; Sylvie Dufour
Journal:  Front Endocrinol (Lausanne)       Date:  2017-08-22       Impact factor: 5.555

8.  Characterization of Gonadotropin-Releasing Hormone (GnRH) Genes From Cartilaginous Fish: Evolutionary Perspectives.

Authors:  Anne-Laure Gaillard; Boon-Hui Tay; Daniela I Pérez Sirkin; Anne-Gaëlle Lafont; Céline De Flori; Paula G Vissio; Sylvie Mazan; Sylvie Dufour; Byrappa Venkatesh; Hervé Tostivint
Journal:  Front Neurosci       Date:  2018-09-06       Impact factor: 4.677

9.  Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in Platynereis.

Authors:  Gabriele Andreatta; Caroline Broyart; Charline Borghgraef; Karim Vadiwala; Vitaly Kozin; Alessandra Polo; Andrea Bileck; Isabel Beets; Liliane Schoofs; Christopher Gerner; Florian Raible
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-16       Impact factor: 11.205
  9 in total

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