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Literature DB >> 3551926

The occurrence of N-methyl-D-aspartic acid in muscle extracts of the blood shell, Scapharca broughtonii.

Abstract

A novel ninhydrin-positive compound, N-methyl-D-aspartic acid, was identified in the muscle extracts of the blood shell, Scapharca broughtonii. This compound is already known to have potent neuroexcitatory activity, inducing hypermotility and strong releasing action of serum luteinizing hormone in mammals. This may be, however, the first finding of N-methyl-D-aspartic acid in natural products.

Entities: Chemical Species

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Year: 1987 PMID： 3551926 PMCID： PMC1147559 DOI： 10.1042/bj2410309

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

16 in total

1. THE EFFECT UPON MICE OF INTRAVENTRICULAR INJECTION OF EXCITANT AND DEPRESSANT AMINO ACIDS.

Authors: J M CRAWFORD
Journal: Biochem Pharmacol Date: 1963-12 Impact factor: 5.858

2. Effect of intraventricular injection of N-methylated GABA-derivatives on the central nervous system of conscious mice.

Authors: T KITA; H KAMIYA; C KIYOTA
Journal: Biochem Pharmacol Date: 1963-02 Impact factor: 5.858

3. The excitation and depression of spinal neurones by structurally related amino acids.

Authors: D R CURTIS; J C WATKINS
Journal: J Neurochem Date: 1960-09 Impact factor: 5.372

4. The action of gamma aminobutyric acid upon cortical electrical activity in the cat.

Authors: K IWAMA; H H JASPER
Journal: J Physiol Date: 1957-10-30 Impact factor: 5.182

5. Effects of gamma-aminobutyric acid on the isolated mammalian ileum.

Authors: F HOBBIGER
Journal: J Physiol Date: 1958-06-18 Impact factor: 5.182

6. Hyperactivity following injection of a glutamate agonist and 6,7-ADTN into rat nucleus accumbens and its inhibition by THIP.

Authors: J Arnt
Journal: Life Sci Date: 1981-04-06 Impact factor: 5.037

7. Acute elevations of serum luteinizing hormone induced by kainic acid, N-methyl aspartic acid or homocysteic acid.

Authors: M T Price; J W Olney; T J Cicero
Journal: Neuroendocrinology Date: 1978 Impact factor: 4.914

8. Magnesium selectively inhibits N-methyl-aspartic acid-induced hypermotility after intra-accumbens injection.

Authors: B A Donzanti; N J Uretsky
Journal: Pharmacol Biochem Behav Date: 1984-02 Impact factor: 3.533

9. Acute central stimulation of luteinizing hormone by parenterally administered N-methyl-D,L-aspartic acid in the male rat.

Authors: B A Schainker; T J Cicero
Journal: Brain Res Date: 1980-02-24 Impact factor: 3.252

10. Actions of aminoacids on the isolated hemisected spinal cord of the toad.

Authors: D R CURTIS; J W PHILLIS; J C WATKINS
Journal: Br J Pharmacol Chemother Date: 1961-06

5 in total

Review 1. D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems.

Authors: Nobutoshi Ota; Ting Shi; Jonathan V Sweedler
Journal: Amino Acids Date: 2012-08-08 Impact factor: 3.520

2. Confirmation of D-aspartic acid in the novel dipeptide beta-aspartylglycine isolated from tissue extract of Aplysia kurodai.

Authors: M Sato; T Yamaguchi; N Kanno; Y Sato
Journal: Biochem J Date: 1989-10-15 Impact factor: 3.857