Clinical, Imaging, Histological and Surgical Aspects Regarding Giant Paraovarian Cysts: A Systematic Review.

Paraovarian cysts (POCs) develop within the broad ligament of the uterus. POCs are considered to be giant when the threshold of 150 mm is exceeded. Clinical signs and symptoms occur as a consequence of the pressure effect on adjacent organs or due to complications. Abdominal ultrasonography, computed tomography or magnetic resonance imaging are useful imaging tools, but most often the exact origin of such voluminous cysts is revealed only by surgical exploration. The review aims to appraise and update the diagnostic, the histological aspects and the treatment of the giant POCs in rare cases. We carried out a systematic search in Medline-PubMed, Google Scholar and ResearchGate electronic databases. Twenty-seven papers fulfilling the selection criteria were included in the review. The data extracted included information about first author, year of publication, country, patient age, size and side of the POCs, symptoms, tumoral markers, imaging methods, preoperative diagnosis, surgical management and histopathological findings. Although not very numerous, all the studies highlighted the low incidence of giant POCs, the impossibility of establishing the origin of the cystic mass by clinical and imaging methods even with advanced technical tools and the low risk of torsion (11.1%). Despite the recognized benign nature of POCs, we found an unexpected high percent (25.9%) of borderline giant POCs. Surgical excision is the only treatment option. Ovarian-sparing surgery was performed in 85.1% of the cases, and minimally invasive techniques were applied in only 42.9% of the patients, which demonstrates the need of a high-level laparoscopic expertise. Knowledge of this pathology, its recognition as a possible etiology of an abdominopelvic cyst, and a higher awareness of the possibility of a borderline histology in giant POCs are required for the proper management of these particular cases.

Introduction

Both paratubal cysts and paraovarian cysts (POCs) are terms which define the same condition: cysts located within the mesosalpinx or the broad ligament.1,2 They can develop from the mesothelium but also from paramesonephric tissues or mesonephric remnants.3,4

POCs represent about 10% of all adnexal masses.5,6 They are the prerogative of reproductive ages being more common in the third or fourth decade of life.7 Only 4% occur in adolescence,8,9 while in postmenopausal women the prevalence is 6.25%.1

The estimated mean size of POCs is 75.1 mm (10–80 mm),10–12 and 95% of them have the diameter smaller than 20 mm.9 There is not an explicit definition of giant POCs. Some authors consider that the size must exceed the threshold of 150 mm,13,14 while others consider that 200 mm is a more appropriate dimension.1

POCs are ordinarily asymptomatic. In cases of giant POCs clinical signs and symptoms occur as a consequence of the pressure effect on adjacent organs or due to complications, such as torsion, rupture or hemorrhage.15,16 Because POCs develop into the broad ligament and have no pedicule, torsion is rare, with 2.1–16% incidence.9 When torsion occurs, it usually involves the fallopian tube, the infundibulopelvic ligament and the ipsilateral ovary.8 Although 97% of POCs are benign,8 borderline or malignant epithelial tumors have also been identified.17,18 Abdominal ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI) are useful imaging tools, but there is a high risk of misdiagnose with ovarian cystic masses because they may not show a clear separation between the cyst and the ipsilateral adnexa.16,19 Most often, the diagnosis becomes evident only during surgical exploration.13,15 In order to preserve fertility, cystectomy with ovarian preservation remains the most appropriate treatment especially in young women or pediatric patients.3,20

The present review aims to systematically appraise and update the diagnostic and histological aspects of giant POCs, as well as the surgical treatment methods applicable in such rare POCs.

Materials and Methods

The research and extraction of eligible studies for the present systematic review were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines (PRISMA).21

Search Strategy

In order to identify all relevant papers in the medical literature, we conducted a comprehensive search in Medline-PubMed, Google Scholar and ResearchGate electronic databases. We focused on the following keywords in different combinations: paraovarian cyst, paratubal cyst, giant, serous cystadenoma, torsion, management. Taking into consideration the rarity of this pathology and the aim of the present review, we did not set a time frame for the publication dates, or a limit on the article type. We also screened the reference list of the selected articles searching for additional eligible publications.

Selection Criteria

Two reviewers worked independently screening all the titles and abstracts. Disagreements were settled through consensus. The inclusion criteria were (1) full-text articles; (2) papers written only in English; (3) patients with POCs larger than 150 mm, regardless of age. Reasons for exclusion were (1) articles which provided insufficient data; (2) articles on solid paraovarian tumors (benign or malignant neoplasms); articles on veterinary pathology.

Data Extraction

Two independent researchers extracted the data after creating a standardized extraction table including information about the first author, year of publication, country, patient age, size and side of the POCs, symptoms, tumoral markers, imaging methods, preoperative diagnosis, surgical management and histopathological findings. Discrepancies were resolved through discussion.

Results

A total of 401 records were identified. The flow diagram of the study selection process is shown in Figure 1. After removing the duplicates and after reviewers #1 and #2 selected papers based on their titles and abstracts, 94 records remained. Both researchers agreed to remove the articles, which did not meet some of the selection criteria. The remaining 53 reports assessed for eligibility were processed by reviewers #3 and #4. Finally, they decided to extract data for the present review from only 27 papers fulfilling the inclusion and exclusion criteria (Table 1).

Figure 1

PRISMA flow diagram of the selection process.

Table 1

The Reported Cases of Giant POCs (Larger Than 150 Mm)

Authors, Year	Age	Size (mm)	Side	Symptoms	Tumoral Markers	Imaging Methods	Preoperative Diagnosis	Surgical Management	Histopathology
Bayar et al, 200626	38	320	R	Pain, IAV, PT	Elevated CA 125	USG, MRI	Abdominal cyst	SOE	Serous papillary cystadenoma
Mukhopadhyay 200615	18	400	L	Pain, IAV, PT	–	USG	Left ovarian cyst	CE, SOE	Simple serous cyst
Kostov et al, 200829	14	300 R 70 L	B	Pain	–	USG	Abdominal tumor	Bilateral CE, RAE	Serous cystadenoma
Saxena et al, 200822	16	300	L	Pain, IAV, PT	–	USG, MRI	Left ovarian cyst	LCE	Serous cystadenoma
Borrás Suñer et al, 200930	25	150	R	Pain, vomiting	Normal	USG	Right ovarian torsion	LCE	Serous papillary cystadenoma
Kiseli et al, 201211	33	300	R	Pain	Normal	USG, MRI	Mesenteric cyst	CE	Serous papillary cystadenoma
Kandil et al, 201331	17	260	L	Pain, IAV, PT	Normal	CT	Left ovarian cyst	CE	Simple serous cyst
Leanza et al, 20135	14	300	R	Pain, IAV, PT	Normal	USG	Right ovarian cyst	LCE	Paramesonephric cyst
Katke et al, 201312	29	350	L	Pregnancy, pain	–	USG, MRI	Mesenteric cyst	CE	Serous cystadenoma
Sagili et al, 20132	25	300 R 400 L	B	Pain, IAV, PT	Normal	USG, CT	Bilateral ovarian cysts	Bilateral CE	Paramesonephric cysts
Asare et al, 201516	19	270	L	IAV	–	USG, CT	Abdominal cyst	CE	Paratubal cyst
Erikci et al, 201520	14	400	L	IAV, PT	Normal	USG, CT	Abdominal cyst	CE, SE	Serous cystadenoma
Shah et al, 201629	16	260	L	Pain, IAV, PT	–	USG, CT	Left ovarian cyst	LCE	Paratubal cyst
Lee et al, 201625	17	190	R	PT	Normal	USG, CT	Right ovarian cyst	LCE, SE	Serous papillary cystadenoma
Gorkem et al, 201627	27	210	R	Pregnancy, pain, PT	Normal	USG, MRI	Abdominal cyst	CE	Serous cystadenoma
Tsuji et al, 201723	25	340	R	Pregnancy, PT	–	USG, MRI	Right ovarian cyst	LCE	Paratubal cyst
Marginean et al, 201819	15	170	L	IAV, PT	–	USG, MRI	Left ovarian cyst	LCE	Serous cyst
Shin et al, 201832	27	160	R	Pain, IAV, PT	Normal	USG CT	Right ovarian cyst	CE	Serous borderline tumor
Agrawal et al, 201810	20	298	R	IAV, PT	Normal	USG CT	Right ovarian cyst	CE	Serous papillary cystadenoma
Skaaf et al, 201913	31	360	R	IAV, PT	Normal	USG CT	Right ovarian cyst	LCE	Paratubal cyst
Alpendre et al, 202033	31	250	R	Pain, vomiting	–	USG CT	Ovarian cyst torsion	AE	Serous papillary cystadenoma
Atileh et al, 202014	32	400	R	IAV, PT	Normal	USG CT	Ovarian cyst	LCE, SE	Serous cystadenoma
Bhansakarya et al, 202034	25	270	R	IAV, PT	Normal	USG CT	Ovarian cyst	LCE	Serous cystadenoma
Zvizdic et al, 202024	15	250	L	Pain, IAV, PT, constip	Normal	USG, MRI	Left ovarian cyst	CE	Serous cystadenoma
Tjokroprawiro et al 20211	30	223	L	IAV, PT	Normal	CT	Left ovarian cyst	CE	Serous benign cyst
Kiran et al, 20213	13	230 R 43 L	B	IAV, PT, vaginal bleeding	Normal	USG CT	Adnexal cyst	LCE	Serous cystadenoma
Čančar et al, 202135	26	580	R	Pain, IAV, PT, constip, dysuria, uterus prolapse	–	USG CT	Abdominal cyst	CE, SE	Simple serous cyst

Abbreviations: R, right; L, left; B, bilateral; IAV, increased abdominal volume; PT, palpable tumor; constip, constipation; USG, ultrasonography; CT, computed tomography; MRI, magnetic resonance imaging; SOE, salpingo-oophorectomy; HE, hysterectomy; LCE, laparoscopic cystectomy; SE, salpingectomy; CE, cystectomy; RAE, right anexectomy; AE, adnexectomy.

We identified 21 case reports, 2 of them associated with a short literature review,1,12 1 short report,22 1 letter to the editor,23 and 4 reviews,11,16,24,25 but none of them included exclusively giant POCs or more than 10 studies.

All the cases were reported by physicians working in University Hospitals from many countries in the world: Turkey,11,20,26,27 India,2,10,12,15,28 Serbia,29 Austria,22 Spain,30 Egypt,31 Italy,5 United States of America,16 South Korea,25,32 Japan,23 Romania,19 Lebanon,13 Portugal,33 Jordan,14 Nepal,34 Bosnia and Herzegovina,24,35 Indonesia,1 and Oman.3

Etiology

In females, both the uterus and the fallopian tubes develop from the paramesonephric (Müllerian) ducts.36 The mesonephric (Wolffian) ducts usually regress, but they may persist as embryonic remnants (epoophoron, paroophoron, Gartner’s ducts).37,38 Depending on their embryological origin, POCs have different location, histological features and evolution. Most often they arise from the peritoneal mesothelium or the paramesonephrotic structures,16 are located along the fallopian tube and are lined by a secretory epithelium responsible for cyst formation.11 In 2% of the cases, POCs are of mesonephric origin,6,9 located near the fimbria, with a non-secretory epithelium.16,39 Moreover, paramesonephric cysts are under hormonal influence, explaining their growth trend and prevalence in postmenarcheal ages,40 as well as their rapid growth in pregnant women.39 When a POC is located at the fimbriated end of the fallopian tube, pedunculated and smaller than 2 cm, it is considered to be a cystic hydatid of Morgagni.11,32,41

Clinical Aspects

We enlisted 27 cases of POCs larger than 150 mm in our review (Table 1). Thirty-seven percent (n = 10) were postmenarcheal pediatric patients (aged under 18 years), and 63% (n = 17) were adult women, with 3 cases of concomitant pregnancy.12,23,27 The only case of postmenopausal patient with a 260 mm POC was reported by Varras et al which was cited by Shah et al and Habek et al.28,42 Regarding the side location, we found 51.8% (n = 14) right-sided cysts, 37% (n = 10) left-sided and 11.1% (n = 3) bilateral.

The clinical signs and symptoms of POCs lack specificity. Most small cysts are asymptomatic, usually discovered during abdomino-pelvic imaging investigations or surgery for other pathologies.5,9,13,14 As the cysts grow, unspecific symptoms may occur, such as recurrent abdomino-pelvic pain, increase in abdominal volume or feeling of weight in the lower abdomen.11 As we found in the literature, the compression of neighboring organs may be reflected by cardiovascular or pulmonary complications,42 dysuria, pollakiuria or hydronephrosis,5,13,15,16,35 constipation,6,9,14,24,35 menstrual irregularities,3,15,25 dyspareunia,5,14 and even uterine prolapse.35 In all cases of giant POCs, the cyst presence may be confirmed by an increased abdominal volume and abdominal palpation. Vaginal bimanual examination (in sexually active patients) is helpful in diagnosing small or medium cysts.5 Like many other conditions (ie, mesenteric cyst, urachal cyst), POCs may also become symptomatic when associated with complications such as intracystic hemorrhage, perforation or torsion.43,44 In such cases, acute pain, hemoperitoneum or even hemorrhagic shock may be present.24 The most frequent and feared complication is ovarian torsion, with a higher probability of occurrence in POCs larger than 50 mm.13,16 Isolated fallopian tube torsion may be encountered, as well.45–47 The patients’ symptoms are acute abdominal pain, vomiting or nausea. Complicated POCs have clinical features similar to acute appendicitis, complicated ovarian cyst, ectopic pregnancy or pelvic inflammatory disease.11,33,48 Although the incidence of POCs in children is lower than in adults, the torsion rate seems to be higher due to a longer and looser infundibulopelvic ligament.40,49 The present literature review found 11.1% (n = 3) cases of torsioned giant POCs,29,30,33 only one case being in a pediatric patient.29 Another potential complication is malignancy, with a reported incidence of 2.9%, mostly in adult patients.39

Imaging Diagnostic and Tumor Markers

The imaging investigation of choice for abdomen or pelvis is USG (transabdominal, transvaginal or transrectal).8,11,14 On USG, uncomplicated cysts are thin-walled, usually unilocular with clear content.1,9 Corroborating the symptoms with the USG images, the differential diagnosis of uncomplicated POCs should include ovarian cyst, mesenteric cyst, abdominal lymphangiomas, pancreatic pseudocyst, echinococcal cyst, cystic intestinal duplication, or cystic mesothelioma.6,16,50 Evocative for POC is the “split sign”, meaning the separation of the cyst from the ovary by pushing the transducer.11,33,40,51 In the study conducted by Gupta et al, USG had a 87.5% accuracy in diagnosing POCs, but the mean diameter of the lesions was 7.5 cm.52 Whenever a cyst torsion is suspected, Doppler studies are mandatory, although the presence of vascular flow may not exclude a twisted ovary.8,11 Findings like papillary projections, septum or intramural nodules should raise the suspicion of borderline or malignant tumor.32,53,54 Whenever an adnexal mass presents imaging signs of malignancy, it is mandatory to test the values of the serum tumor markers: CA 125, carcinoembryonic antigen (CEA), lactate dehydrogenase (LDH), alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (β HCG).11,30 These markers could be useful in differentiating between benign and malignant cysts, although their values are elevated in only 54% of the adnexal malignant neoplasms and in 6.5% of the benign lesions.13,55 There are insufficient studies on the predictive value of CA 125 levels for malignant POCs.1

CT or MRI seem to be more accurate in showing a delineation between the unilocular cystic lesion and a normal ovary.3,24,48 The MRI is preferred, because it avoids radiation, which is essential especially in pediatric patients.5,56 Despite the technical imaging progress, the correct diagnosis is usually established by abdominopelvic surgical exploration.11,16,57 Barloon et al cited by Tjokroprawiro found that only 1 out of 15 (6.66%) patients received a correct diagnosis before surgery.1 The present literature review revealed that none of the giant POCs were correctly diagnosed, and in 62.9% (n = 17) of the cases, the preoperative diagnosis was ovarian cyst. Other preoperative diagnoses were abdominal cyst or tumor (n = 6), mesenteric cyst (n = 2), and ovarian torsion (n = 2). As the findings above show, it seems unlikely to establish the origin within the broad ligament of a giant abdomino-pelvic cyst by clinical and imaging methods. Moreover, the diagnosis of POC has not been considered in the differential diagnosis in any of the cases found in the literature.

Treatment Options

POCs larger than 30 mm should be excised, due to their constant growth and torsion risk.20,24,40 Smaller cysts may be aspirated, but there is a high risk of recurrence.8 It is obvious that the appropriate way to treat giant POCs is the surgical excision, but there is no consensus on whether it should be by laparoscopic or open techniques.1,58 Generally, the limiting factors for laparoscopy are the giant size of the mass, the signs of malignancy or an insufficient expertise of the surgeon.28,33 Whether open or minimally invasive techniques are preferred, the preoperative administration of dexamethasone has a prophylactic effect on postoperative nausea and vomiting.59 The anesthesiologists prefer the inhalational induction with sevoflurane, because of its rapid action, pleasant odor and absence of airways irritation,60 but they should be aware of the intraoperative allergic reactions caused by the neuromuscular blocking agents.61 The literature review showed that open surgery has been preferred by 57.1% (n = 16) of the authors, with 8 cases of midline incision,1,10,11,20,29,32,33,35 2 of Pfannenstiel incision,16,24 and 1 of paramedian incision.15 In the last decade, there have been reported 22 giant POCs, but only 9 (40.9%) were treated laparoscopically, and in all these cases, an open-entry technique was used transumbilical,5,25 in the left umbilical fold,22 supraumbilical,3,13,29 subumbilical,14 or in Palmer’s point.34 Aspirating the cyst content was mandatory for an accurate diagnosis and for an easier cyst dissection. The cyst drainage was performed with the Veress needle,22,34 or with a high pressure suction cannula introduced transumbilically. In order to avoid the spillage of the fluid in the peritoneal cavity, surgeons may use a closed system (wound protector, a purse-string suture around the trocar).13,14 We also found one case of laparoscopic excision through a minilaparotomy without pneumoperitoneum, in a pregnant woman,23 and one case of laparo-endoscopic single-site surgery for a borderline POC.25 The main purpose of the treatment should be sparing the ovarian tissue necessary to preserve fertility as well as to a proper sexual development of the pediatric patients. Cystectomy is the standard treatment,1,3,11 but removal of a giant POC sometimes requires associated tubal excision or even oophorectomy. The present review found only 70.3% (n = 19) cystectomies. There were 4 cases of associated salpingectomy,14,20,25,35 2 salpingo-oophorectomies,15,26 and 2 adnexectomies.29,33

Histopathological Aspects

Histopathologically, POCs are mostly benign: simple cysts (74.6%) and benign neoplastic lesions (25.4%) – cystadenomas and cystadenofibromas.11,24,52 Malignant or borderline paraovarian epithelial tumors have also been reported.20,28 Borderline tumors (of low malignant potential) are defined by malignant features without stromal invasion.25,32 Reviewing the literature we found the following histopathological types of giant POCs: 33.3% (n = 9) serous cystadenomas,3,12,14,20,22,24,27,29,34 18.5% (n = 5) simple serous cysts,1,15,19,31,35 22.2% (n = 6) paratubal/paraovarian cysts,13,16,23,28 7.4% (n = 2) paramesonephric cyst,2,5 and 25.9% (n = 7) borderline serous papillary cystadenomas (only one in a 17-year-old patient).10,11,25,26,30,32,33

We found an unexpected high percentage (25%) of borderline giant POCs. Serum marker testing was indicated in 17 cases, but Ca 125 levels were elevated only in the case reported by Bayar et al.26 Of the 7 cases included in the present review, papillary projections inside the cyst were found on USG,26,32 on CT,11,25 or intraoperatively.10,30,33 Some authors recommend supplementary intraoperative measures for cyst’s drainage in these situations, as well as the confirmation of cyst malignancy by frozen sections.1,44

Conclusions

Although not very numerous, all the studies highlighted the low incidence of giant POCs, the impossibility of establishing the origin of the cystic mass by clinical and imaging methods even with advanced technical tools and the low risk of torsion. Despite the recognized benign nature of the giant POCs, the present review found 25% of the lesions to be borderline tumors. Surgical excision is the only treatment option. Ovarian-sparing surgery was performed in 85.1% of cases, and minimally invasive techniques were applied in only 42.9% of the patients, which demonstrates the need for a high-level laparoscopic expertise.

Knowledge of this pathology, its recognition as a possible etiology of an abdominopelvic cyst, and a higher awareness of the possibility of a borderline histology in giant POCs are required for the proper management of these particular cases.