Gabriel Ribeiro Dos Santos1, Darunee Buddhari2, Sopon Iamsirithaworn3, Direk Khampaen3, Alongkot Ponlawat4, Thanyalak Fansiri4, Aaron Farmer2, Stefan Fernandez2, Stephen Thomas5,6,7, Isabel Rodriguez Barraquer8, Anon Srikiatkhachorn9,10, Angkana T Huang1,2, Derek A T Cummings11,12, Timothy Endy5,6,7,13, Alan L Rothman9, Henrik Salje1,11, Kathryn B Anderson2,5,6,7. 1. Department of Genetics, University of Cambridge, United Kingdom. 2. Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. 3. Department of Disease Control, Ministry of Public Health, Tiwanond, Nonthaburi, Thailand. 4. Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. 5. Department of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA. 6. Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA. 7. Institute for Global Health and Translational Sciences, SUNY Upstate Medical University, Syracuse, New York, USA. 8. Department of Medicine, University of California, San Francisco, San Francisco, California, USA. 9. Department of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhone Island, USA. 10. Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand. 11. Department of Biology, University of Florida, Gainesville, USA. 12. Emerging Pathogens Institute, University of Florida, Gainesville, USA. 13. Coalition for Epidemic Preparedness Innovations (CEPI), Washington, District of Columbia, USA.
Abstract
BACKGROUND: Dengue virus (DENV) often circulates endemically. In such settings with high levels of transmission, it remains unclear whether there are risk factors that alter individual infection risk. METHODS: We tested blood taken from individuals living in multigenerational households in Kamphaeng Phet province, Thailand for DENV antibodies (N = 2364, mean age 31 years). Seropositivity ranged from 45.4% among those 1-5 years old to 99.5% for those >30 years. Using spatially explicit catalytic models, we estimated that 11.8% of the susceptible population gets infected annually. RESULTS: We found that 37.5% of the variance in seropositivity was explained by unmeasured household-level effects with only 4.2% explained by spatial differences between households. The serostatus of individuals from the same household remained significantly correlated even when separated by up to 15 years in age. CONCLUSIONS: These findings show that despite highly endemic transmission, persistent differences in infection risk exist across households, the reasons for which remain unclear.
BACKGROUND: Dengue virus (DENV) often circulates endemically. In such settings with high levels of transmission, it remains unclear whether there are risk factors that alter individual infection risk. METHODS: We tested blood taken from individuals living in multigenerational households in Kamphaeng Phet province, Thailand for DENV antibodies (N = 2364, mean age 31 years). Seropositivity ranged from 45.4% among those 1-5 years old to 99.5% for those >30 years. Using spatially explicit catalytic models, we estimated that 11.8% of the susceptible population gets infected annually. RESULTS: We found that 37.5% of the variance in seropositivity was explained by unmeasured household-level effects with only 4.2% explained by spatial differences between households. The serostatus of individuals from the same household remained significantly correlated even when separated by up to 15 years in age. CONCLUSIONS: These findings show that despite highly endemic transmission, persistent differences in infection risk exist across households, the reasons for which remain unclear.
Authors: Laura C Harrington; Thomas W Scott; Kriangkrai Lerdthusnee; Russell C Coleman; Adriana Costero; Gary G Clark; James J Jones; Sangvorn Kitthawee; Pattamaporn Kittayapong; Ratana Sithiprasasna; John D Edman Journal: Am J Trop Med Hyg Date: 2005-02 Impact factor: 2.345
Authors: Thi Ty Hang Vu; Edward C Holmes; Veasna Duong; Thien Quy Nguyen; Tinh Hien Tran; Michael Quail; Carol Churcher; Julian Parkhill; Jane Cardosa; Jeremy Farrar; Bridget Wills; Niall J Lennon; Bruce W Birren; Philippe Buchy; Matthew R Henn; Cameron P Simmons Journal: PLoS Negl Trop Dis Date: 2010-07-20
Authors: Kathryn B Anderson; Darunee Buddhari; Anon Srikiatkhachorn; Gregory D Gromowski; Sopon Iamsirithaworn; Alden L Weg; Damon W Ellison; Louis Macareo; Derek A T Cummings; In-Kyu Yoon; Ananda Nisalak; Alongkot Ponlawat; Stephen J Thomas; Stefan Fernandez; Richard G Jarman; Alan L Rothman; Timothy P Endy Journal: Am J Epidemiol Date: 2020-07-01 Impact factor: 4.897
Authors: In-Kyu Yoon; Arthur Getis; Jared Aldstadt; Alan L Rothman; Darunee Tannitisupawong; Constantianus J M Koenraadt; Thanyalak Fansiri; James W Jones; Amy C Morrison; Richard G Jarman; Ananda Nisalak; Mammen P Mammen; Suwich Thammapalo; Anon Srikiatkhachorn; Sharone Green; Daniel H Libraty; Robert V Gibbons; Timothy Endy; Chusak Pimgate; Thomas W Scott Journal: PLoS Negl Trop Dis Date: 2012-07-17
Authors: Derek A T Cummings; Sopon Iamsirithaworn; Justin T Lessler; Aidan McDermott; Rungnapa Prasanthong; Ananda Nisalak; Richard G Jarman; Donald S Burke; Robert V Gibbons Journal: PLoS Med Date: 2009-09-01 Impact factor: 11.069
Authors: Kathryn B Anderson; Anna M Stewart-Ibarra; Darunee Buddhari; Efrain Felix Beltran Ayala; Rachel J Sippy; Sopon Iamsirithaworn; Sadie J Ryan; Stefan Fernandez; Richard G Jarman; Stephen J Thomas; Timothy P Endy Journal: Front Public Health Date: 2020-02-12