Carlo Giussani1,2, Andrea Trezza3, Vittorio Ricciuti3,4, Andrea Di Cristofori3,4, Andrea Held3,4, Valeria Isella5,6, Maura Massimino7. 1. Neurosurgery, School of Medicine and Surgery, Neuroscience Center, University of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy. carlo.giussani@unimib.it. 2. Azienda Socio Sanitaria Territoriale - Monza, Neurosurgery Unit, Ospedale San Gerardo Via Pergolesi 33, 20900, Monza, (MB, Italy. carlo.giussani@unimib.it. 3. Neurosurgery, School of Medicine and Surgery, Neuroscience Center, University of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy. 4. Azienda Socio Sanitaria Territoriale - Monza, Neurosurgery Unit, Ospedale San Gerardo Via Pergolesi 33, 20900, Monza, (MB, Italy. 5. Ospedale San Gerardo, University of Milano - Bicocca, Monza, Italy. 6. Milan Center for Neuroscience (NeuroMI), Milan, Italy. 7. Pediatric Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Abstract
PURPOSE: The extent of brain tumor resection (EOR) is a fundamental prognostic factor in pediatric neuro-oncology in association with the histology. In general, resection aims at gross total resection (GTR). Intraoperative imaging like intraoperative US (iOUS) and MRI have been developed in order to find any tumoral remnant but with different costs. Aim of our work is to review the current literature in order to better understand the differences between costs and efficacy of MRI and iOUS to evaluate tumor remnants intraoperatively. METHODS: We reviewed the existing literature on PubMed until 31st December 2021 including the sequential keywords "intraoperative ultrasound and pediatric brain tumors", "iUS and pediatric brain tumors", "intraoperative magnetic resonance AND pediatric brain tumors", and "intraoperative MRI AND pediatric brain tumors. RESULTS: A total of 300 papers were screened through analysis of title and abstract; 254 were excluded. After selection, a total of 23 articles were used for this systematic review. Among the 929 patients described, a total of 349(38%) of the cases required an additional resection after an iMRI scan. GTR was measured on 794 patients (data of 69 patients lost), and it was achieved in 552(70%) patients. In case of iOUS, GTR was estimated in 291 out of 379 (77%) cases. This finding was confirmed at the post-operative MRI in 256(68%) cases. CONCLUSIONS: The analysis of the available literature demonstrates that expensive equipment does not always mean better. In fact, for the majority of pediatric brain tumors, iOUS is comparable to iMRI in estimating the EOR.
PURPOSE: The extent of brain tumor resection (EOR) is a fundamental prognostic factor in pediatric neuro-oncology in association with the histology. In general, resection aims at gross total resection (GTR). Intraoperative imaging like intraoperative US (iOUS) and MRI have been developed in order to find any tumoral remnant but with different costs. Aim of our work is to review the current literature in order to better understand the differences between costs and efficacy of MRI and iOUS to evaluate tumor remnants intraoperatively. METHODS: We reviewed the existing literature on PubMed until 31st December 2021 including the sequential keywords "intraoperative ultrasound and pediatric brain tumors", "iUS and pediatric brain tumors", "intraoperative magnetic resonance AND pediatric brain tumors", and "intraoperative MRI AND pediatric brain tumors. RESULTS: A total of 300 papers were screened through analysis of title and abstract; 254 were excluded. After selection, a total of 23 articles were used for this systematic review. Among the 929 patients described, a total of 349(38%) of the cases required an additional resection after an iMRI scan. GTR was measured on 794 patients (data of 69 patients lost), and it was achieved in 552(70%) patients. In case of iOUS, GTR was estimated in 291 out of 379 (77%) cases. This finding was confirmed at the post-operative MRI in 256(68%) cases. CONCLUSIONS: The analysis of the available literature demonstrates that expensive equipment does not always mean better. In fact, for the majority of pediatric brain tumors, iOUS is comparable to iMRI in estimating the EOR.
Authors: Daniel J Indelicato; Julie A Bradley; Ronny L Rotondo; Ronica H Nanda; Natalie Logie; Eric S Sandler; Philipp R Aldana; Nathan J Ranalli; Alexandra D Beier; Christopher G Morris; Nancy P Mendenhall Journal: Acta Oncol Date: 2017-12-14 Impact factor: 4.089
Authors: Prayash Patel; David Wallace; Frederick A Boop; Brandy Vaughn; Giles W Robinson; Amar Gajjar; Paul Klimo Journal: Neurosurgery Date: 2019-05-01 Impact factor: 4.654
Authors: Eric M Thompson; Thomas Hielscher; Eric Bouffet; Marc Remke; Betty Luu; Sridharan Gururangan; Roger E McLendon; Darell D Bigner; Eric S Lipp; Sebastien Perreault; Yoon-Jae Cho; Gerald Grant; Seung-Ki Kim; Ji Yeoun Lee; Amulya A Nageswara Rao; Caterina Giannini; Kay Ka Wai Li; Ho-Keung Ng; Yu Yao; Toshihiro Kumabe; Teiji Tominaga; Wieslawa A Grajkowska; Marta Perek-Polnik; David C Y Low; Wan Tew Seow; Kenneth T E Chang; Jaume Mora; Ian F Pollack; Ronald L Hamilton; Sarah Leary; Andrew S Moore; Wendy J Ingram; Andrew R Hallahan; Anne Jouvet; Michelle Fèvre-Montange; Alexandre Vasiljevic; Cecile Faure-Conter; Tomoko Shofuda; Naoki Kagawa; Naoya Hashimoto; Nada Jabado; Alexander G Weil; Tenzin Gayden; Takafumi Wataya; Tarek Shalaby; Michael Grotzer; Karel Zitterbart; Jaroslav Sterba; Leos Kren; Tibor Hortobágyi; Almos Klekner; Bognár László; Tímea Pócza; Peter Hauser; Ulrich Schüller; Shin Jung; Woo-Youl Jang; Pim J French; Johan M Kros; Marie-Lise C van Veelen; Luca Massimi; Jeffrey R Leonard; Joshua B Rubin; Rajeev Vibhakar; Lola B Chambless; Michael K Cooper; Reid C Thompson; Claudia C Faria; Alice Carvalho; Sofia Nunes; José Pimentel; Xing Fan; Karin M Muraszko; Enrique López-Aguilar; David Lyden; Livia Garzia; David J H Shih; Noriyuki Kijima; Christian Schneider; Jennifer Adamski; Paul A Northcott; Marcel Kool; David T W Jones; Jennifer A Chan; Ana Nikolic; Maria Luisa Garre; Erwin G Van Meir; Satoru Osuka; Jeffrey J Olson; Arman Jahangiri; Brandyn A Castro; Nalin Gupta; William A Weiss; Iska Moxon-Emre; Donald J Mabbott; Alvaro Lassaletta; Cynthia E Hawkins; Uri Tabori; James Drake; Abhaya Kulkarni; Peter Dirks; James T Rutka; Andrey Korshunov; Stefan M Pfister; Roger J Packer; Vijay Ramaswamy; Michael D Taylor Journal: Lancet Oncol Date: 2016-03-12 Impact factor: 41.316