Literature DB >> 35509767

A Comparative Study on Efficacy of Negative Pressure Wound Therapy Versus Standard Wound Therapy for Patients With Compound Fractures in a Tertiary Care Hospital.

Arun Kumaar1, Arun H Shanthappa1, Prabhu Ethiraj1.   

Abstract

BACKGROUND: Orthopedic surgeons face a difficult task in treating serious open fractures, which usually result in complications, morbidity, and even amputation. Compound fracture wounds were traditionally treated with a standard saline dressing. To avoid infection and problems during therapy, several studies found that open fractures require early skeletal stability as well as soft tissue repair. In favoring the above fact vacuum-assisted closure (VAC) is now undergoing a paradigm shift. With this background, this study aimed to compare the effects of VAC dressing versus standard wound dressing on compound fracture wounds.
METHODOLOGY: This study has been conducted as a single-blind randomized control trial among 128 patients who got admitted to the Department of Orthopedics, R L Jalappa Hospital attached to Sri Devaraj Urs Medical College, Karnataka, India from August 2019 to November 2021. The study participants were randomly allotted into two groups negative pressure wound therapy (NPWT) and standard wound therapy (SWT) consisting of 64 participants in each group. VAC dressing was used on group NPWT, while normal saline wound dressing was used on group SWT. Both groups were followed up for a month after their discharge from the hospital. Frequency in dressing changes wound healing time, infection presence, and hospitalization days were all recorded and compared over one month. The data collection was done using questionnaires and the statistical analysis was done with SPSS version 21 (Chicago, IL: IBM Corp.).
RESULTS: There was a statically significant difference favoring group NPWT compared to group SWT with a hospital stay, number of dressings required, wound size reduction, wound healing time, and deep infection rate (p<0.05).
CONCLUSIONS: The use of NPWT speeds up the healing of compound fracture wounds significantly. It is affordable and can be used as a substitute in resource-constrained areas to reduce infection and manage open fracture wounds quickly.
Copyright © 2022, Kumaar et al.

Entities:  

Keywords:  angiogenesis; compound fracture; negative pressure wound therapy; standard wound therapy; trauma; vacuum assisted closure

Year:  2022        PMID: 35509767      PMCID: PMC9060726          DOI: 10.7759/cureus.23727

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  20 in total

Review 1.  Negative pressure wound therapy (NPWT) for spinal wounds: a systematic review.

Authors:  Karen J Ousey; Ross A Atkinson; J Bradley Williamson; Steve Lui
Journal:  Spine J       Date:  2013-08-24       Impact factor: 4.166

Review 2.  Negative pressure wound therapy for partial-thickness burns.

Authors:  Jo C Dumville; Christopher Munson; Janice Christie
Journal:  Cochrane Database Syst Rev       Date:  2014-12-15

3.  Impact of negative pressure wound therapy on open diaphyseal tibial fractures: A prospective randomized trial.

Authors:  Siddharth R Virani; Aditya A Dahapute; S S Bava; Saurabh R Muni
Journal:  J Clin Orthop Trauma       Date:  2016-07-16

Review 4.  Evidence-based recommendations for the use of Negative Pressure Wound Therapy in traumatic wounds and reconstructive surgery: steps towards an international consensus.

Authors:  E Krug; L Berg; C Lee; D Hudson; H Birke-Sorensen; M Depoorter; R Dunn; S Jeffery; F Duteille; A Bruhin; C Caravaggi; M Chariker; C Dowsett; F Ferreira; J M Francos Martínez; G Grudzien; S Ichioka; R Ingemansson; M Malmsjo; P Rome; S Vig; N Runkel; R Martin; J Smith
Journal:  Injury       Date:  2011-02       Impact factor: 2.586

5.  Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.

Authors:  R B Gustilo; J T Anderson
Journal:  J Bone Joint Surg Am       Date:  1976-06       Impact factor: 5.284

6.  Negative pressure wound therapy reduces deep infection rate in open tibial fractures.

Authors:  Martin L Blum; Max Esser; Martin Richardson; Eldho Paul; Franklin L Rosenfeldt
Journal:  J Orthop Trauma       Date:  2012-09       Impact factor: 2.512

Review 7.  Negative pressure wound therapy for skin grafts and surgical wounds healing by primary intention.

Authors:  Joan Webster; Paul Scuffham; Karen L Sherriff; Monica Stankiewicz; Wendy P Chaboyer
Journal:  Cochrane Database Syst Rev       Date:  2012-04-18

8.  Negative pressure wound therapy after severe open fractures: a prospective randomized study.

Authors:  James P Stannard; David A Volgas; Rena Stewart; Gerald McGwin; Jorge E Alonso
Journal:  J Orthop Trauma       Date:  2009-09       Impact factor: 2.512

9.  Protocol for a randomised controlled trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients with an open fracture of the lower limb: UK Wound management of Lower Limb Fractures (UK WOLLF).

Authors:  Juul Achten; Nick R Parsons; Julie Bruce; Stavros Petrou; Elizabeth Tutton; Keith Willett; Sarah E Lamb; Matthew L Costa
Journal:  BMJ Open       Date:  2015-09-22       Impact factor: 2.692

10.  Comparison of negative pressure wound therapy (NPWT) &conventional wound dressings in the open fracture wounds.

Authors:  Hamidreza Arti; Mohsen Khorami; Vahid Ebrahimi-Nejad
Journal:  Pak J Med Sci       Date:  2016 Jan-Feb       Impact factor: 1.088

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