Literature DB >> 35508105

PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.

Xu Chen1, Riccardo Calandrelli2, John Girardini3, Zhangming Yan2, Zhiqun Tan4, Xiangmin Xu5, Annie Hiniker6, Sheng Zhong7.   

Abstract

Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
Copyright © 2022 Elsevier Inc. All rights reserved.

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Year:  2022        PMID： 35508105      PMCID： PMC9531314          DOI： 10.1016/j.cmet.2022.02.008

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   31.373


  10 in total

1.  Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease.

Authors:  David C Hondius; Pim van Nierop; Ka Wan Li; Jeroen J M Hoozemans; Roel C van der Schors; Elise S van Haastert; Saskia M van der Vies; Annemieke J M Rozemuller; August B Smit
Journal:  Alzheimers Dement       Date:  2016-01-06       Impact factor: 21.566

2.  Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.

Authors:  Juliette Le Douce; Marianne Maugard; Julien Veran; Marco Matos; Pierrick Jégo; Pierre-Antoine Vigneron; Emilie Faivre; Xavier Toussay; Michel Vandenberghe; Yaël Balbastre; Juliette Piquet; Elvire Guiot; Nguyet Thuy Tran; Myriam Taverna; Stéphane Marinesco; Ayumi Koyanagi; Shigeki Furuya; Mylène Gaudin-Guérif; Sébastien Goutal; Aurélie Ghettas; Alain Pruvost; Alexis-Pierre Bemelmans; Marie-Claude Gaillard; Karine Cambon; Lev Stimmer; Véronique Sazdovitch; Charles Duyckaerts; Graham Knott; Anne-Sophie Hérard; Thierry Delzescaux; Philippe Hantraye; Emmanuel Brouillet; Bruno Cauli; Stéphane H R Oliet; Aude Panatier; Gilles Bonvento
Journal:  Cell Metab       Date:  2020-03-03       Impact factor: 27.287

3.  A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.

Authors:  Nicholas T Seyfried; Eric B Dammer; Vivek Swarup; Divya Nandakumar; Duc M Duong; Luming Yin; Qiudong Deng; Tram Nguyen; Chadwick M Hales; Thomas Wingo; Jonathan Glass; Marla Gearing; Madhav Thambisetty; Juan C Troncoso; Daniel H Geschwind; James J Lah; Allan I Levey
Journal:  Cell Syst       Date:  2016-12-15       Impact factor: 10.304

4.  Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.

Authors:  Jung Hoon Yang; Akira Wada; Kazuyuki Yoshida; Yurika Miyoshi; Tomoko Sayano; Kayoko Esaki; Masami O Kinoshita; Shozo Tomonaga; Norihiro Azuma; Masahiko Watanabe; Kenji Hamase; Kiyoshi Zaitsu; Takeo Machida; Albee Messing; Shigeyoshi Itohara; Yoshio Hirabayashi; Shigeki Furuya
Journal:  J Biol Chem       Date:  2010-10-21       Impact factor: 5.157

5.  A vicious cycle of β amyloid-dependent neuronal hyperactivation.

Authors:  Benedikt Zott; Manuel M Simon; Wei Hong; Felix Unger; Hsing-Jung Chen-Engerer; Matthew P Frosch; Bert Sakmann; Dominic M Walsh; Arthur Konnerth
Journal:  Science       Date:  2019-08-09       Impact factor: 47.728

6.  The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle.

Authors:  Samah Neame; Hazem Safory; Inna Radzishevsky; Ayelet Touitou; Francesco Marchesani; Marialaura Marchetti; Shai Kellner; Shai Berlin; Veronika N Foltyn; Simone Engelender; Jean-Marie Billard; Herman Wolosker
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-23       Impact factor: 11.205

7.  Presymptomatic Increase of an Extracellular RNA in Blood Plasma Associates with the Development of Alzheimer's Disease.

Authors:  Zhangming Yan; Zixu Zhou; Qiuyang Wu; Zhen Bouman Chen; Edward H Koo; Sheng Zhong
Journal:  Curr Biol       Date:  2020-03-26       Impact factor: 10.834

8.  NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.

Authors:  Ran Inoue; Kenji Hashimoto; Tomomi Harai; Hisashi Mori
Journal:  J Neurosci       Date:  2008-12-31       Impact factor: 6.167

9.  Single-cell transcriptomic analysis of Alzheimer's disease.

Authors:  Hansruedi Mathys; Jose Davila-Velderrain; Zhuyu Peng; Fan Gao; Shahin Mohammadi; Jennie Z Young; Madhvi Menon; Liang He; Fatema Abdurrob; Xueqiao Jiang; Anthony J Martorell; Richard M Ransohoff; Brian P Hafler; David A Bennett; Manolis Kellis; Li-Huei Tsai
Journal:  Nature       Date:  2019-05-01       Impact factor: 49.962

Review 10.  Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer.

Authors:  Gerson D Guercio; Rogerio Panizzutti
Journal:  Front Psychiatry       Date:  2018-02-05       Impact factor: 4.157
  10 in total

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