| Literature DB >> 3550723 |
I Ganzetti, V De Gennaro, M Redaelli, E E Müller, D Cocchi.
Abstract
Long-term (7 and 14 days) hypophysectomy resulted in a striking decrease in growth hormone releasing hormone-like immunoreactivity (GHRH-LI) in the median eminence (ME) of adult male rats, evaluated by both radioimmunoassay and immunohistochemistry. Treatment with human GH (125 micrograms/rat, twice daily IP for 14 days) prevented, though partially, depletion of GHRH-LI from the ME, as assessed by both methods. These results demonstrate that circulating GH levels regulate the function of GHRH-producing structures, via a feedback mechanism.Entities:
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Year: 1986 PMID： 3550723 DOI： 10.1016/0196-9781(86)90130-0
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750