Literature DB >> 35506116

Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism.

U Madhusudhan1, Kalpana M1, Vidya Singaravelu2, Vidya Ganji1, Nitin John1, Archana Gaur1.   

Abstract

Brain-derived neurotrophic factor (BDNF), which is expressed at high levels in the limbic system, has been shown to regulate learning, memory and cognition. Thyroid hormone is crucial for brain development. Hypothyroidism is a clinical condition in which thyroid hormones are reduced and it affects the growth and development of the brain in neonates and progresses to cognitive impairment in adults. The exact mechanism of how reduced thyroid hormones impairs cognition and memory is not well understood. This review explores the possible role of BDNF-mediated cognitive impairment in hypothyroid patients.
Copyright © 2022, Madhusudhan et al.

Entities:  

Keywords:  cognition; memory; neurotrophin; p75ntr; thyroid disorder

Year:  2022        PMID： 35506116      PMCID： PMC9056880          DOI： 10.7759/cureus.23722

Source DB:  PubMed          Journal:  Cureus        ISSN： 2168-8184


  57 in total

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Authors:  Clive R Bramham; Elhoucine Messaoudi
Journal:  Prog Neurobiol       Date:  2005-06       Impact factor: 11.685

3.  Hippocampal size and memory functioning in children and adolescents with congenital hypothyroidism.

Authors:  Sarah M Wheeler; Karen A Willoughby; Mary Pat McAndrews; Joanne F Rovet
Journal:  J Clin Endocrinol Metab       Date:  2011-06-22       Impact factor: 5.958

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Journal:  J Neuroendocrinol       Date:  2013-03       Impact factor: 3.627

Review 5.  Wrapped to Adapt: Experience-Dependent Myelination.

Authors:  Christopher W Mount; Michelle Monje
Journal:  Neuron       Date:  2017-08-16       Impact factor: 17.173

6.  Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain.

Authors:  Lynette A Desouza; Uma Ladiwala; Sarah M Daniel; Shubhada Agashe; Rama A Vaidya; Vidita A Vaidya
Journal:  Mol Cell Neurosci       Date:  2005-07       Impact factor: 4.314

7.  Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression.

Authors:  Igor Branchi; Nina N Karpova; Ivana D'Andrea; Eero Castrén; Enrico Alleva
Journal:  Neurosci Lett       Date:  2011-03-21       Impact factor: 3.046

8.  Verbal memory retrieval deficits associated with untreated hypothyroidism.

Authors:  Karen J Miller; Thomas D Parsons; Peter C Whybrow; Katja Van Herle; Natalie Rasgon; Andre Van Herle; Dorothy Martinez; Dan H Silverman; Michael Bauer
Journal:  J Neuropsychiatry Clin Neurosci       Date:  2007       Impact factor: 2.198

9.  Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

Authors:  M Korte; P Carroll; E Wolf; G Brem; H Thoenen; T Bonhoeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-12       Impact factor: 11.205

10.  CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes.

Authors:  Marie E Bechler; Lauren Byrne; Charles Ffrench-Constant
Journal:  Curr Biol       Date:  2015-08-27       Impact factor: 10.834
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