Literature DB >> 35505033

Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer.

Mladen Korbelik1, Zdzislaw M Szulc2, Alicja Bielawska2, Duska Separovic3.   

Abstract

Recently, it has become clear that a prerequisite requirement for most cancer therapies is controlling the negative impact of the activity of immunosuppressory cell populations. It is therefore of a considerable interest to develop treatments for containing the operation of major myeloid and lymphoid immunoregulatory cell populations. We have reported that acid ceramidase inhibitor LCL521 effectively overrides the activity of immunoregulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) engaged in the context of tumor response to photodynamic therapy (PDT). The present communication dissects and describes in detail the procedure for the use of LCL521 as an adjuvant to PDT for improved cure rates of treated tumors based on restricting the activity of immunoregulatory cell populations.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Ceramidase; Immunoregulatory cell populations; LCL521; Photodynamic therapy; Tumor response

Mesh：

Year:  2022        PMID： 35505033     DOI： 10.1007/978-1-0716-2099-1_28

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  26 in total

Review 1.  Acid ceramidase and human disease.

Authors:  Jae-Ho Park; Edward H Schuchman
Journal:  Biochim Biophys Acta       Date:  2006-09-01

Review 2.  Myeloid-derived suppressor cells in cancer: recent progress and prospects.

Authors:  Yazan S Khaled; Basil J Ammori; Eyad Elkord
Journal:  Immunol Cell Biol       Date:  2013-06-25       Impact factor: 5.126

Review 3.  Regulatory T cells in tumor immunity.

Authors:  Hiroyoshi Nishikawa; Shimon Sakaguchi
Journal:  Int J Cancer       Date:  2010-08-15       Impact factor: 7.396

Review 4.  Improving cancer immunotherapy by targeting tumor-induced immune suppression.

Authors:  Trina J Stewart; Mark J Smyth
Journal:  Cancer Metastasis Rev       Date:  2011-03       Impact factor: 9.264

Review 5.  A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death.

Authors:  Tarek A Taha; Thomas D Mullen; Lina M Obeid
Journal:  Biochim Biophys Acta       Date:  2006-11-01

6.  Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.

Authors:  Mladen Korbelik; Judit Banáth; Wei Zhang; Kyi Min Saw; Zdzislaw M Szulc; Alicja Bielawska; Duska Separovic
Journal:  Int J Cancer       Date:  2016-05-18       Impact factor: 7.396

7.  Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression.

Authors:  Sheng Xiao; Hulin Jin; Thomas Korn; Sue M Liu; Mohamed Oukka; Bing Lim; Vijay K Kuchroo
Journal:  J Immunol       Date:  2008-08-15       Impact factor: 5.422

Review 8.  Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy.

Authors:  Michal Baniyash
Journal:  Cancer Immunol Immunother       Date:  2016-05-25       Impact factor: 6.968

9.  Cyclophosphamide-induced myeloid-derived suppressor cell population is immunosuppressive but not identical to myeloid-derived suppressor cells induced by growing TC-1 tumors.

Authors:  Romana Mikyšková; Marie Indrová; Veronika Polláková; Jana Bieblová; Jana Símová; Milan Reiniš
Journal:  J Immunother       Date:  2012-06       Impact factor: 4.456

Review 10.  Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer.

Authors:  Juan R Cubillos-Ruiz; Eslam Mohamed; Paulo C Rodriguez
Journal:  J Immunother Cancer       Date:  2017-01-17       Impact factor: 13.751
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