Literature DB >> 35505009

A Perfusion Model to Evaluate Response to Photodynamic Therapy in 3D Tumors.

Shubhankar Nath1, Michael Pigula1, Tayyaba Hasan1,2, Imran Rizvi3.   

Abstract

Numerous cancer models have been developed to investigate the effects of mechanical stress on the biology of cells. Here we describe a protocol to fabricate a perfusion model to culture 3-dimensional (3D) ovarian cancer nodules under constant flow. The modular design of this model allows for a wide range of treatment regimens and combinations, including PDT and chemotherapy. Finally, methods for a number of readouts are detailed, allowing researchers to investigate a variety of biological and cytotoxic parameters related to mechanical stress and therapeutic modalities.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  3D tumor; Fluid stress; Mechanotransduction; Ovarian cancer; Perfusion model; Shear stress;  Photodynamic therapy

Mesh：

Substances：

Year:  2022        PMID： 35505009     DOI： 10.1007/978-1-0716-2099-1_4

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  19 in total

Review 1.  Capturing complex 3D tissue physiology in vitro.

Authors:  Linda G Griffith; Melody A Swartz
Journal:  Nat Rev Mol Cell Biol       Date:  2006-03       Impact factor: 94.444

Review 2.  Microfluidic 3D cell culture: from tools to tissue models.

Authors:  Vincent van Duinen; Sebastiaan J Trietsch; Jos Joore; Paul Vulto; Thomas Hankemeier
Journal:  Curr Opin Biotechnol       Date:  2015-06-19       Impact factor: 9.740

3.  How does the extracellular matrix direct gene expression?

Authors:  M J Bissell; H G Hall; G Parry
Journal:  J Theor Biol       Date:  1982-11-07       Impact factor: 2.691

Review 4.  Putting tumours in context.

Authors:  M J Bissell; D Radisky
Journal:  Nat Rev Cancer       Date:  2001-10       Impact factor: 60.716

5.  Mechanotransduction of fluid stresses governs 3D cell migration.

Authors:  William J Polacheck; Alexandra E German; Akiko Mammoto; Donald E Ingber; Roger D Kamm
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-03       Impact factor: 11.205

6.  Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.

Authors:  Ioannis K Zervantonakis; Shannon K Hughes-Alford; Joseph L Charest; John S Condeelis; Frank B Gertler; Roger D Kamm
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-06       Impact factor: 11.205

7.  Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules.

Authors:  Imran Rizvi; Umut A Gurkan; Savas Tasoglu; Nermina Alagic; Jonathan P Celli; Lawrence B Mensah; Zhiming Mai; Utkan Demirci; Tayyaba Hasan
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-03       Impact factor: 11.205

8.  Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery.

Authors:  Fotios Mpekris; Stelios Angeli; Athanassios P Pirentis; Triantafyllos Stylianopoulos
Journal:  Biomech Model Mechanobiol       Date:  2015-05-13

9.  Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow.

Authors:  Gizem Calibasi Kocal; Sinan Güven; Kira Foygel; Aaron Goldman; Pu Chen; Shiladitya Sengupta; Ramasamy Paulmurugan; Yasemin Baskin; Utkan Demirci
Journal:  Sci Rep       Date:  2016-12-02       Impact factor: 4.379

10.  Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery.

Authors:  Kristin Stock; Marta F Estrada; Suzana Vidic; Kjersti Gjerde; Albin Rudisch; Vítor E Santo; Michaël Barbier; Sami Blom; Sharath C Arundkar; Irwin Selvam; Annika Osswald; Yan Stein; Sylvia Gruenewald; Catarina Brito; Wytske van Weerden; Varda Rotter; Erwin Boghaert; Moshe Oren; Wolfgang Sommergruber; Yolanda Chong; Ronald de Hoogt; Ralph Graeser
Journal:  Sci Rep       Date:  2016-07-01       Impact factor: 4.379
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