Literature DB >> 35503176

Sphingomyelin Synthase Family and Phospholipase Cs.

Xian-Cheng Jiang1, Yeun-Po Chiang2.   

Abstract

The sphingomyelin synthase (SMS) gene family has three members: SMS1 and SMS2 have SM synthase activity, while SMS-related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. Recently, we found that SMS family members are a group of phospholipase Cs (PLC). SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC. SMS family members not only influence SM levels but also influence the levels of diacylglycerol (DAG), PC, PE, and glycosphingolipids, thus influencing cell functions. In this chapter, we will discuss the recent progress in the research field of SMS family and will focus on its impact on metabolic diseases.
© 2022. The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd.

Entities:  

Keywords:  Metabolic diseases; Phospholipase C; Sphingomyelin synthase

Mesh：

Substances：

Year:  2022        PMID： 35503176      PMCID： PMC9251732          DOI： 10.1007/978-981-19-0394-6_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   3.650


  73 in total

1.  An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases.

Authors:  A F Neuwald
Journal:  Protein Sci       Date:  1997-08       Impact factor: 6.725

2.  Selective reduction in the sphingomyelin content of atherogenic lipoproteins inhibits their retention in murine aortas and the subsequent development of atherosclerosis.

Authors:  Yifan Fan; Fujun Shi; Jing Liu; Jibin Dong; Hai H Bui; David A Peake; Ming-Shang Kuo; Guoqing Cao; Xian-Cheng Jiang
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-09-02       Impact factor: 8.311

3.  Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.

Authors:  Fikadu G Tafesse; Ana M Vacaru; Elleke F Bosma; Martin Hermansson; Amrita Jain; Angelika Hilderink; Pentti Somerharju; Joost C M Holthuis
Journal:  J Cell Sci       Date:  2013-11-20       Impact factor: 5.285

4.  Human sphingomyelin synthase 1 gene (SMS1): organization, multiple mRNA splice variants and expression in adult tissues.

Authors:  Alexandra V Rozhkova; Veronika G Dmitrieva; Olga N Zhapparova; Olga Yu Sudarkina; Elena S Nadezhdina; Svetlana A Limborska; Lyudmila V Dergunova
Journal:  Gene       Date:  2011-04-29       Impact factor: 3.688

5.  Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis.

Authors:  S Ichikawa; H Sakiyama; G Suzuki; K I Hidari; Y Hirabayashi
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

6.  Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.

Authors:  Jing Liu; Hongqi Zhang; Zhiqiang Li; Tiruneh K Hailemariam; Mahua Chakraborty; Kailiu Jiang; Daniel Qiu; Hai H Bui; David A Peake; Ming-Shang Kuo; Raj Wadgaonkar; Guoqing Cao; Xian-Cheng Jiang
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-03-12       Impact factor: 8.311

7.  The domain responsible for sphingomyelin synthase (SMS) activity.

Authors:  Calvin Yeang; Shweta Varshney; Renxiao Wang; Ya Zhang; Deyong Ye; Xian-Cheng Jiang
Journal:  Biochim Biophys Acta       Date:  2008-07-23

8.  The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression.

Authors:  Lyudmila V Dergunova; Alexandra V Rozhkova; Olga Yu Sudarkina; Svetlana A Limborska
Journal:  Mol Biol Rep       Date:  2013-09-24       Impact factor: 2.316

9.  Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis.

Authors:  Eun Hee Koh; Ji Eun Yoon; Myoung Seok Ko; Jaechan Leem; Ji-Young Yun; Chung Hwan Hong; Yun Kyung Cho; Seung Eun Lee; Jung Eun Jang; Ji Yeon Baek; Hyun Ju Yoo; Su Jung Kim; Chang Ohk Sung; Joon Seo Lim; Won-Il Jeong; Sung Hoon Back; In-Jeoung Baek; Sandra Torres; Estel Solsona-Vilarrasa; Laura Conde de la Rosa; Carmen Garcia-Ruiz; Ariel E Feldstein; Jose C Fernandez-Checa; Ki-Up Lee
Journal:  Gut       Date:  2020-11-18       Impact factor: 23.059

10.  Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.

Authors:  Ana M Vacaru; Fikadu G Tafesse; Philipp Ternes; Vangelis Kondylis; Martin Hermansson; Jos F H M Brouwers; Pentti Somerharju; Catherine Rabouille; Joost C M Holthuis
Journal:  J Cell Biol       Date:  2009-06-08       Impact factor: 10.539
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