Songsong Yuan1, Xingzhi Huang2, Xiaoping Wu1, Pan Xu2, Aiyun Zhou2. 1. Department of Infectious Disease, the First Affiliated Hospital of Nanchang University, Nanchang, China. 2. Department of Ultrasonography, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Abstract
Background: To evaluate the accuracy of two-dimensional (2D) shear wave elastography (SWE), develop and validate a novel prognostic model in predicting acute-on-chronic liver failure (ACLF) development in patients with acutely decompensated hepatitis B cirrhosis. Methods: This prospective cohort study enrolled 221 patients in the First Affiliated Hospital of Nanchang University from September 2019 to January 2021, and randomly assigned them to the derivation and validation cohorts (7:3 ratio). Ultrasound, 2D SWE, clinical and laboratory data were collected, and outcome (ACLF developed) was recorded during a 90-day follow-up period. We evaluated the ability of 2D SWE to predict the outcome, developed a model for predicting ACLF development in the derivation cohort, and assessed the model in the validation cohort. Results: 2D SWE values were significantly higher in patients with ACLF development (P<0.05). The accuracy of 2D SWE in predicting the outcome was better than that of serum parameters of liver fibrosis (all P<0.05). The SWE model for ACLF development had good calibration and discrimination [concordance index (C-index): 0.855 and 0.840 respectively] in derivation and validation cohorts, outperforming serum prognostic scores (all P<0.05). Conclusions: The SWE model, superior to serum prognostic scores in predicting ACLF development, could be a noninvasive tool to guide the individual management of patients with acutely decompensated hepatitis B cirrhosis. 2022 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Background: To evaluate the accuracy of two-dimensional (2D) shear wave elastography (SWE), develop and validate a novel prognostic model in predicting acute-on-chronic liver failure (ACLF) development in patients with acutely decompensated hepatitis B cirrhosis. Methods: This prospective cohort study enrolled 221 patients in the First Affiliated Hospital of Nanchang University from September 2019 to January 2021, and randomly assigned them to the derivation and validation cohorts (7:3 ratio). Ultrasound, 2D SWE, clinical and laboratory data were collected, and outcome (ACLF developed) was recorded during a 90-day follow-up period. We evaluated the ability of 2D SWE to predict the outcome, developed a model for predicting ACLF development in the derivation cohort, and assessed the model in the validation cohort. Results: 2D SWE values were significantly higher in patients with ACLF development (P<0.05). The accuracy of 2D SWE in predicting the outcome was better than that of serum parameters of liver fibrosis (all P<0.05). The SWE model for ACLF development had good calibration and discrimination [concordance index (C-index): 0.855 and 0.840 respectively] in derivation and validation cohorts, outperforming serum prognostic scores (all P<0.05). Conclusions: The SWE model, superior to serum prognostic scores in predicting ACLF development, could be a noninvasive tool to guide the individual management of patients with acutely decompensated hepatitis B cirrhosis. 2022 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Authors: Thierry Gustot; Javier Fernandez; Elisabet Garcia; Filippo Morando; Paolo Caraceni; Carlo Alessandria; Wim Laleman; Jonel Trebicka; Laure Elkrief; Corinna Hopf; Pablo Solís-Munoz; Faouzi Saliba; Stefan Zeuzem; Augustin Albillos; Daniel Benten; José Luis Montero-Alvarez; Maria Teresa Chivas; Mar Concepción; Juan Córdoba; Aiden McCormick; Rudolf Stauber; Wolfgang Vogel; Andrea de Gottardi; Tania M Welzel; Marco Domenicali; Alessandro Risso; Julia Wendon; Carme Deulofeu; Paolo Angeli; François Durand; Marco Pavesi; Alexander Gerbes; Rajiv Jalan; Richard Moreau; Pere Ginés; Mauro Bernardi; Vicente Arroyo Journal: Hepatology Date: 2015-05-29 Impact factor: 17.425
Authors: Christoph F Dietrich; Jeffrey Bamber; Annalisa Berzigotti; Simona Bota; Vito Cantisani; Laurent Castera; David Cosgrove; Giovanna Ferraioli; Mireen Friedrich-Rust; Odd Helge Gilja; Ruediger Stephan Goertz; Thomas Karlas; Robert de Knegt; Victor de Ledinghen; Fabio Piscaglia; Bogdan Procopet; Adrian Saftoiu; Paul S Sidhu; Ioan Sporea; Maja Thiele Journal: Ultraschall Med Date: 2017-04-13 Impact factor: 6.548
Authors: Siddharth Singh; Larissa L Fujii; Mohammad Hassan Murad; Zhen Wang; Sumeet K Asrani; Richard L Ehman; Patrick S Kamath; Jayant A Talwalkar Journal: Clin Gastroenterol Hepatol Date: 2013-08-15 Impact factor: 11.382
Authors: T F Karlas; C Pfrepper; J Rosendahl; C Benckert; C Wittekind; S Jonas; J Moessner; M Tröltzsch; H L Tillmann; T Berg; V Keim; J Wiegand Journal: Z Gastroenterol Date: 2011-04-07 Impact factor: 2.000
Authors: Rajiv Jalan; Faouzi Saliba; Marco Pavesi; Alex Amoros; Richard Moreau; Pere Ginès; Eric Levesque; Francois Durand; Paolo Angeli; Paolo Caraceni; Corinna Hopf; Carlo Alessandria; Ezequiel Rodriguez; Pablo Solis-Muñoz; Wim Laleman; Jonel Trebicka; Stefan Zeuzem; Thierry Gustot; Rajeshwar Mookerjee; Laure Elkrief; German Soriano; Joan Cordoba; Filippo Morando; Alexander Gerbes; Banwari Agarwal; Didier Samuel; Mauro Bernardi; Vicente Arroyo Journal: J Hepatol Date: 2014-06-17 Impact factor: 25.083
Authors: Jonel Trebicka; Javier Fernandez; Maria Papp; Paolo Caraceni; Wim Laleman; Carmine Gambino; Ilaria Giovo; Frank Erhard Uschner; Christian Jansen; Cesar Jimenez; Rajeshwar Mookerjee; Thierry Gustot; Agustin Albillos; Rafael Bañares; Peter Jarcuska; Christian Steib; Thomas Reiberger; Juan Acevedo; Pietro Gatti; Debbie L Shawcross; Stefan Zeuzem; Alexander Zipprich; Salvatore Piano; Thomas Berg; Tony Bruns; Karen Vagner Danielsen; Minneke Coenraad; Manuela Merli; Rudolf Stauber; Heinz Zoller; José Presa Ramos; Cristina Solé; Germán Soriano; Andrea de Gottardi; Henning Gronbaek; Faouzi Saliba; Christian Trautwein; Haluk Tarik Kani; Sven Francque; Stephen Ryder; Pierre Nahon; Manuel Romero-Gomez; Hans Van Vlierberghe; Claire Francoz; Michael Manns; Elisabet Garcia-Lopez; Manuel Tufoni; Alex Amoros; Marco Pavesi; Cristina Sanchez; Michael Praktiknjo; Anna Curto; Carla Pitarch; Antonella Putignano; Esau Moreno; William Bernal; Ferran Aguilar; Joan Clària; Paola Ponzo; Zsuzsanna Vitalis; Giacomo Zaccherini; Boglarka Balogh; Alexander Gerbes; Victor Vargas; Carlo Alessandria; Mauro Bernardi; Pere Ginès; Richard Moreau; Paolo Angeli; Rajiv Jalan; Vicente Arroyo Journal: J Hepatol Date: 2020-11-20 Impact factor: 25.083