| Literature DB >> 35501892 |
Mahul Chakraborty1, Arunachalam Ramaiah1,2,3, Adriana Adolfi4, Paige Halas4, Bhagyashree Kaduskar2,3, Luna Thanh Ngo1, Suvratha Jayaprasad5, Kiran Paul5, Saurabh Whadgar5, Subhashini Srinivasan3,5, Suresh Subramani3,6,7, Ethan Bier2,7, Anthony A James4,7,8, J J Emerson9,10.
Abstract
Entities:
Year: 2022 PMID: 35501892 PMCID: PMC9059397 DOI: 10.1186/s12915-022-01314-2
Source DB: PubMed Journal: BMC Biol ISSN: 1741-7007 Impact factor: 7.364
Fig. 3Gene expression changes in adult female mosquitoes after a blood meal. a Transcript abundance of genes that are in the top 1% (> ~ 64-fold) of the PBM transcript abundance changes. As evident here, more genes show upregulation than downregulation, although expression changes of some genes may not be due to the blood meal. b GO gene enrichment analysis of the genes from panel a. Consistent with the role of the blood meal in mosquito biology, the genes involved in cell division, DNA replication, amino acid metabolism, and cell signaling are enriched among the differentially expressed genes. c Protein sequence identity between the An. stephensi genes showing PBM upregulation and their An. gambiae orthologs. d Despite being a common genetic marker, the sequence of the PBM upregulated white gene was fragmented in the draft assembly of An. stephensi. e Transcript abundance of four yellow genes (yellow, yellow-b, yellow-e, yellow-g) before and after a blood meal. All genes show a similar transcript profile until 6 h PBM, after which yellow-g transcripts become more abundant. f A Cyp450 orthologous to D. melanogaster Cyp305a1 shows PBM upregulation and harbors intronic TEs are absent in the Jiang et al. [18] assembly