| Literature DB >> 35501356 |
Maud Pascal1,2,3, Alexander Kazakov4, Gabriel Lepousez5, Pierre-Marie Lledo6, Christoph Wilhelm4, Gérard Eberl7, Grégoire Chevalier8, Lola Dubrule5, Julie Deyrat5, Alice Dupin5, Soham Saha5, Ferdinand Jagot8, Kurt Sailor5, Sophie Dulauroy8, Carine Moigneu5, Yasmine Belkaid9.
Abstract
The nervous system and the immune system both rely on an extensive set of modalities to perceive and act on perturbations in the internal and external environments. During feeding, the intestine is exposed to nutrients that may contain noxious substances and pathogens. Here we show that Vasoactive Intestinal Peptide (VIP), produced by the nervous system in response to feeding, potentiates the production of effector cytokines by intestinal type 2 and type 3 innate lymphoid cells (ILC2s and ILC3s). Exposure to VIP alone leads to modest activation of ILCs, but strongly potentiates ILCs to concomitant or subsequent activation by the inducer cytokines IL-33 or IL-23, via mobilization of cAMP and energy by glycolysis. Consequently, VIP increases resistance to intestinal infection by the helminth Trichuris muris and the enterobacteria Citrobacter rodentium. These findings uncover a functional neuro-immune crosstalk unfolding during feeding that increases the reactivity of innate immunity necessary to face potential threats associated with food intake.Entities:
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Year: 2022 PMID： 35501356 DOI： 10.1038/s41385-022-00516-9
Source DB: PubMed Journal: Mucosal Immunol ISSN： 1933-0219 Impact factor: 8.701