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Literature DB >> 35495565

The Cell as Matter: Connecting Molecular Biology to Cellular Functions.

Abstract

Viewing cell as matter to understand the intracellular biomolecular processes and multicellular tissue behavior represents an emerging research area at the interface of physics and biology. Cellular material displays various physical and mechanical properties, which can strongly affect both intracellular and multicellular biological events. This review provides a summary of how cells, as matter, connect molecular biology to cellular and multicellular scale functions. As an impact in molecular biology, we review recent progresses in utilizing cellular material properties to direct cell fate decisions in the communities of immune cells, neurons, stem cells, and cancer cells. Finally, we provide an outlook on how to integrate cellular material properties in developing biophysical methods for engineered living systems, regenerative medicine, and disease treatments.

Entities: Chemical

Year: 2021 PMID： 35495565 PMCID： PMC9053450 DOI： 10.1016/j.matt.2021.03.013

Source DB: PubMed Journal: Matter ISSN： 2590-2385

198 in total

Review 1. Mechanosignaling to the cell nucleus and gene regulation.

Authors: G V Shivashankar
Journal: Annu Rev Biophys Date: 2011 Impact factor: 12.981

2. Mechanical stability of the cell nucleus - roles played by the cytoskeleton in nuclear deformation and strain recovery.

Authors: Xian Wang; Haijiao Liu; Min Zhu; Changhong Cao; Zhensong Xu; Yonit Tsatskis; Kimberly Lau; Chikin Kuok; Tobin Filleter; Helen McNeill; Craig A Simmons; Sevan Hopyan; Yu Sun
Journal: J Cell Sci Date: 2018-07-04 Impact factor: 5.285

3. B cell activation is regulated by the stiffness properties of the substrate presenting the antigens.

Authors: Zhengpeng Wan; Shaosen Zhang; Yilin Fan; Kai Liu; Feng Du; Angel M Davey; Huiyuan Zhang; Weidong Han; Chunyang Xiong; Wanli Liu
Journal: J Immunol Date: 2013-04-03 Impact factor: 5.422

Review 4. Dynamic structural remodelling of microglia in health and disease: a review of the models, the signals and the mechanisms.

Authors: F Rohan Walker; Sarah B Beynon; Kimberley A Jones; Zidan Zhao; Ratchaniporn Kongsui; Murray Cairns; Michael Nilsson
Journal: Brain Behav Immun Date: 2014-01-08 Impact factor: 7.217

5. Nuclear envelope rupture and repair during cancer cell migration.

Authors: Celine M Denais; Rachel M Gilbert; Philipp Isermann; Alexandra L McGregor; Mariska te Lindert; Bettina Weigelin; Patricia M Davidson; Peter Friedl; Katarina Wolf; Jan Lammerding
Journal: Science Date: 2016-03-24 Impact factor: 47.728

Review 6. Cell tension, matrix mechanics, and cancer development.

Authors: Sui Huang; Donald E Ingber
Journal: Cancer Cell Date: 2005-09 Impact factor: 31.743

7. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis.

Authors: Albertomaria Moro; Tristan P Driscoll; Liana C Boraas; William Armero; Dionna M Kasper; Nicolas Baeyens; Charlene Jouy; Venkatesh Mallikarjun; Joe Swift; Sang Joon Ahn; Donghoon Lee; Jing Zhang; Mengting Gu; Mark Gerstein; Martin Schwartz; Stefania Nicoli
Journal: Nat Cell Biol Date: 2019-02-11 Impact factor: 28.824

8. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.

Authors: Si Ming Man; Andrew Ekpenyong; Panagiotis Tourlomousis; Sarra Achouri; Eugenia Cammarota; Katherine Hughes; Alessandro Rizzo; Gilbert Ng; John A Wright; Pietro Cicuta; Jochen R Guck; Clare E Bryant
Journal: Proc Natl Acad Sci U S A Date: 2014-11-24 Impact factor: 11.205

The Cell as Matter: Connecting Molecular Biology to Cellular Functions.

Review 1. Mechanosignaling to the cell nucleus and gene regulation.

2. Mechanical stability of the cell nucleus - roles played by the cytoskeleton in nuclear deformation and strain recovery.

3. B cell activation is regulated by the stiffness properties of the substrate presenting the antigens.

Review 4. Dynamic structural remodelling of microglia in health and disease: a review of the models, the signals and the mechanisms.

5. Nuclear envelope rupture and repair during cancer cell migration.

Review 6. Cell tension, matrix mechanics, and cancer development.

7. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis.

8. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.

9. A fluid-to-solid jamming transition underlies vertebrate body axis elongation.

Review 10. Unraveling the mechanobiology of immune cells.

Review 1. Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine.

2. Deep-learning-based 3D cellular force reconstruction directly from volumetric images.